Publication Name	World Journal of Cardiology
Manuscript ID	36002
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Observational Study
Article Title	Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair
Manuscript Source	Unsolicited Manuscript
All Author List	Benjamin Steven Frank, Tracy T Urban, Suhong Tong, Courtney Cassidy, Max B Mitchell, Christopher S Nichols and Jesse A Davidson
Funding Agency and Grant Number	Funding Agency Grant Number NIH/NCATS Colorado CTSA UL1 TR001082-04
Corresponding Author	Benjamin Steven Frank, MD, Academic Fellow, Division of Cardiology, Department of Pediatrics, University of Colorado Denver, 13123 E. 16th Ave, Box B100, Aurora, CO 80045, United States. benjamin.frank@childrenscolorado.org
Key Words	Biomarkers; Cardiac remodeling; Pediatric; Neonate; Left ventricular hypertrophy
Core Tip	Patients with coarctation of the aorta are at risk for a variety of short- and long-term complications after surgical repair. Endothelin-1 (ET-1) is a peptide hormone known to cause both cardiac myocyte hypertrophy and vasoconstriction that has been linked to late ventricular hypertrophy in this population. Peri-operative endothelin concentration in this population has not been previously defined. We demonstrate that neonates with coarctation of the aorta have high pre-operative ET-1 levels that decrease post-operatively. Older coarctation patients have more modest ET-1 activation that is unchanged post-operatively. These findings suggest two distinct patterns of ET-1 activation within this population.
Citation	Frank BS, Urban TT, Tong S, Cassidy C, Mitchell MB, Nichols CS, Davidson JA. Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair. World J Cardiol 2017; 9(12): 822-829

Received	2017-08-25 01:45
Peer-Review Started	2017-08-25 06:23
To Make the First Decision	2017-09-25 00:46
Return for Revision	2017-09-25 08:13
Revised	2017-10-09 21:26
Second Decision	2017-11-06 08:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-10 18:39
Articles in Press	2017-11-10 18:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-12-19 08:27

ISSN	1949-8462 (online)
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