Publication Name	World Journal of Gastroenterology
Manuscript ID	36189
Country	Poland

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Intestinal parameters of oxidative imbalance in celiac adults with extraintestinal manifestations
Manuscript Source	Invited Manuscript
All Author List	Agnieszka Piatek-Guziewicz, Agata Ptak-Belowska, Magdalena Przybylska-Felus, Pawel Pasko, Pawel Zagrodzki, Thomas Brzozowski, Tomasz Hubert Mach and Malgorzata Zwolinska-Wcislo
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Higher Education K/ZDS/003811
Corresponding Author	Thomas Brzozowski, MD, PhD, Professor, Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, Cracow 31-531, Poland. mpbrzozo@cyf-kr.edu.pl
Key Words	Celiac disease; Oxidative stress; Superoxide dismutase; Heat-shock protein 70; Apoptosis; Hypoxia-inducible factor; Uric acid; Vitamin D; Tumor necrosis factor alpha
Core Tip	Oxidative stress has been implicated in gliadin toxicity. Additional measures aimed at reducing oxidative imbalance may prove to be effective supplementary therapy. We demonstrated increased duodenal expression of hypoxia-inducible factor 1 (HIF-1α), heat-shock protein 70 (HSP-70), and superoxide dismutase in adult celiac patients with extraintestinal manifestations as a defensive reaction to oxidative stress. Hence, HSP-70 and HIF-1α might be potential novel biomarkers of celiac disease (CD). Increased HSP-70 expression, both in treated and untreated celiac patients, suggests that oxidative stress as well as histopathological alterations in duodenal mucosa persist despite GFD. Our data confirm the increased serum levels of uric acid in patients with CD compared with controls as a result of oxidative stress.
Citation	Piatek-Guziewicz A, Ptak-Belowska A, Przybylska-Felus M, Pasko P, Zagrodzki P, Brzozowski T, Mach T, Zwolinska-Wcislo M. Intestinal parameters of oxidative imbalance in celiac adults with extraintestinal manifestations. World J Gastroenterol 2017; 23(44): 7849-7862

Received	2017-10-11 00:38
Peer-Review Started	2017-10-11 06:45
To Make the First Decision	2017-10-18 06:47
Return for Revision	2017-10-19 11:52
Revised	2017-11-03 17:48
Second Decision	2017-11-14 06:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-11-14 18:49
Articles in Press	2017-11-14 18:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-11-20 07:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com