BPG is committed to discovery and dissemination of knowledge
Articles in Press
11/14/2017 7:01:44 PM | Browse: 241 | Download: 1040
Publication Name World Journal of Gastroenterology
Manuscript ID 36362
Country/Territory China
Category Integrative & Complementary Medicine
Manuscript Type Basic Study
Article Title Pharmacokinetics and pharmacodynamics of shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injuries
Manuscript Source Unsolicited Manuscript
All Author List Lv Zhu, Jun-Yi Li, Yu-Mei Zhang, Hong-Xin Kang, Huan Chen, Hang Su, Juan Li and Wen-Fu Tang
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China 81603519
the National Natural Science Foundation of China 81573857
the National Natural Science Foundation of China 81374042
Corresponding Author Wen-Fu Tang, PhD, Professor, Sichuan Provincial Pancreatitis Center, Department of Integrative Medicine, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, Sichuan Province, China. tangwf@scu.edu.cn
Key Words Shengjiang decoction; Pharmacokinetics; Pharmacodynamics; Pancreatic distribution; Acute pancreatitis
Core Tip Shengjiang decoction (SJD) has been identified effectively in treating acute pancreatitis (AP) in vivo and in vitro tests. We report the metabolic processes of major components of SJD in vivo and the pharmacodynamic mechanism of SJD in relieving AP the first time. This study demonstrated that AP may have varying effects on the pharmacokinetics of the major SJD components in rats. Rhein and bisdemethoxycurcumin may be potential active components for the treatment of AP based on the hypothesis of tissue pharmacology of herbal recipe. SJD may attenuate AP by regulating inflammatory responses to protect against multiple organ injuries.
Citation Zhu L, Li JY, Zhang YM, Kang HX, Chen H, Su H, Li J, Tang WF. Pharmacokinetics and pharmacodynamics of Shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injury. World J Gastroenterol 2017; 23(46): 8169-8181
Received
2017-09-20 00:43
Peer-Review Started
2017-09-20 06:40
To Make the First Decision
2017-10-11 01:03
Return for Revision
2017-10-13 01:23
Revised
2017-10-24 09:55
Second Decision
2017-11-14 06:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-11-14 19:01
Articles in Press
2017-11-14 19:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
2017-11-20 13:44
Typeset the Manuscript
2017-12-06 00:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provide the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com