Publication Name	World Journal of Clinical Cases
Manuscript ID	36864
Country	Japan

Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Fatal fulminant herpes simplex hepatitis following surgery in an adult
Manuscript Source	Unsolicited Manuscript
All Author List	Yoshihiro Yokoi, Takeshi Kaneko, Tomoki Sawayanagi, Yasuo Takano and Yoichi Watahiki
Funding Agency and Grant Number
Corresponding Author	Yoshihiro Yokoi, MD, Doctor, Department of Surgery, Shinshiro Municipal Hospital, 32-1 Kitahata, Shinshiro 441-1387, Japan. y.yokoi@shinshirohp.jp
Key Words	Herpes simplex virus; Fulminant hepatitis; Postsurgical; Adult; Acyclovir
Core Tip	Fatal fulminant herpetic hepatitis developed in a 72-year-old healthy man following ordinary surgery for biliary stones. A. sudden onset of hepatitis associated with high fever and leukopenia emerged on postoperative day 5, followed by a rapid and lethal course (died on day 9), despite an acyclovir treatment on day 8. A literature review showed that (1): A wide spectrum of surgical procedures is involved; and (2): High mortality (87%) associated with low rates of ante-mortem diagnosis (20%) and acyclovir treatment (20%). An early clinical suspension and prompt empirical anti-viral intervention are imperative for postsurgical hepatitis with undetermined etiology, characterized by fever and leucopenia.
Citation	Yokoi Y, Kaneko T, Sawayanagi T, Takano Y, Watahiki Y. Fatal fulminant herpes simplex hepatitis following surgery in an adult. World J Clin Cases 2018; 6(2): 11-19

Received	2017-11-04 07:03
Peer-Review Started	2017-11-04 11:23
To Make the First Decision	2017-11-30 01:17
Return for Revision	2017-11-30 09:24
Revised	2017-12-15 10:31
Second Decision	2018-01-08 00:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-01-16 21:17
Articles in Press	2018-01-16 21:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-02-05 05:57

ISSN	2307-8960 (online)
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