Publication Name	World Journal of Gastroenterology
Manuscript ID	36951
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions
Manuscript Source	Invited Manuscript
All Author List	Abdel-Rahman Zekri, Somaya El Deeb, Abeer Bahnassy, Abeer Badr, Mona S. Abdellateif, Gamal Esmat, Hosny Salama, Marwa Mohanad, Ahmed Esam El-dien, Shimaa Rabah and Assmaa Abd Elkader
Funding Agency and Grant Number
Corresponding Author	Abdel-Rahman Zekri, MSc, PhD, Professor, Molecular Virology and Immunology Unit, Department of Cancer Biology, National Cancer Institute, Cairo University, Kasr Al-Aini Street, Fom El-Khaleeg, Cairo 11976, Egypt. ncizekri@yahoo.com
Key Words	Hepatocellular carcinoma; Hepatitis C virus; NKG2D; CD40; interleukin-2; interleukin-10; myeloid dendritic cells; plasmacytoid cells; natural killer cell; Cytokines
Core Tip	We assessed the levels of different immune modulatory cytokines and innate immune cells as natural killer (NK) cells and dendritic cells (DCs) in patients with disease progression of hepatocarcinogenesis. Our results showed significant down-regulation in active mDCs and pDCs expressing CD40 as well as NK cells expressing NKG2D. The expression of NKG2D on NKs was not expressed in 63% of hepatocellular carcinoma (HCC) patients. Also, there was significant decrease of interleukin (IL)-2, interferon-α and interferon-γ, and a significant increase in IL-10, IL-1β, and TNF-αR2 in HCC patients. These factors could be implicated in the pathogenesis of HCC, and represent attractive targets for therapy in chronic hepatitis C virus hepatitis and HCC.
Citation	Zekri AN, El Deeb S, Bahnassy AA, Badr AM, Abdellateif MS, Esmat G, Salama H, Mohanad M, El-dien AE, Rabah S, Abd Elkader A. Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions. World J Gastroenterol 2018; 24(11): 1228-1238

Received	2017-11-05 17:02
Peer-Review Started	2017-11-06 00:54
To Make the First Decision	2017-11-22 01:08
Return for Revision	2017-11-27 06:46
Revised	2017-12-24 07:31
Second Decision	2018-01-16 12:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-01-16 17:25
Articles in Press	2018-01-16 17:25
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-01-27 20:14
Typeset the Manuscript	2018-03-15 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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