Publication Name	World Journal of Gastroenterology
Manuscript ID	37288
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Translational pancreatic cancer research: A comparative study on patient-derived xenograft models
Manuscript Source	Unsolicited Manuscript
All Author List	Mercedes Rubio-Manzanares Dorado, Luis Miguel Marín Gómez, Daniel Aparicio Sánchez, Sheila Pereira Arenas, Juan Manuel Praena-Fernández, Juan Jose Borrero Martín, Francisco Farfán López, Miguel Ángel Gómez Bravo, Jordi Muntané Relat and Javier Padillo Ruiz
Funding Agency and Grant Number	Funding Agency Grant Number the Andalusian Public Foundation for the Management of Health Research in Seville (FISEVI)
Corresponding Author	Mercedes Rubio-Manzanares Dorado, MD, PhD, Staff Physician, Department of Hepatobiliary and Pancreatic Surgery, Virgen del Rocio Universitary Hospital, Manuel Siurot St, Seville 41013, Spain. mercedesrmd@gmail.com
Key Words	Immunohistological analysis; Pancreatic cancer; Patient-derived xenograft; Animal model; Nude mice
Core Tip	Several investigations have established patient-derived xenograft models for breast, renal, head and neck cancer, and hepatocellular tumours. Some of these models have predicted the clinical response of a specific type of tumour to different chemotherapeutic agents. However, the morphological and histological features of human pancreatic cancer xenografts in experimental models have been poorly studied. In the present study, the effectiveness of three experimental models based on the implantation of patient pancreatic cancer in three different locations (subcutaneous, intraperitoneal and pancreatic) have been assessed for the first time.
Citation	Rubio-Manzanares Dorado M, Marín Gómez LM, Aparicio Sánchez D, Pereira Arenas S, Praena-Fernández JM, Borrero Martín JJ, Farfán López F, Gómez Bravo MÁ, Muntané Relat J, Padillo Ruiz J. Translational pancreatic cancer research: A comparative study on patient-derived xenograft models. World J Gastroenterol 2018; 24(7): 794-809

Received	2017-12-02 14:24
Peer-Review Started	2017-12-02 17:23
To Make the First Decision	2017-12-20 07:49
Return for Revision	2017-12-21 03:51
Revised	2018-01-15 16:59
Second Decision	2018-01-18 10:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-01-18 15:08
Articles in Press	2018-01-18 15:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-01-27 20:32
Typeset the Manuscript	2018-02-08 08:03

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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