Publication Name	World Journal of Gastroenterology
Manuscript ID	37358
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging for predicting histological grade of hepatocellular carcinoma: Comparison with conventional diffusion-weighted imaging
Manuscript Source	Unsolicited Manuscript
All Author List	Shao-Cheng Zhu, Yue-Hua Liu, Yi Wei, Lin-Lin Li, She-Wei Dou, Ting-Yi Sun and Da-Peng Shi
Funding Agency and Grant Number
Corresponding Author	Shao-Cheng Zhu, MD, PhD, Chief Doctor, Professor, Department of Radiology, Henan Provincial People’s Hospital, No. 7, Weiwu Road, Zhengzhou 450003, Henan Province, China. 104753150948@vip.henu.edu.cn
Key Words	Intravoxel incoherent motion; Diffusion-weighted imaging; Hepatocellular carcinoma; Pathological differentiation grade
Core Tip	Intravoxel incoherent motion (IVIM)-based diffusion-weighted imaging (DWI) can yield diffusion and perfusion information simultaneously. The aims of this study were to compare IVIM-derived parameters with conventional DWI parameters for predicting the histological grade of hepatocellular carcinomas (HCCs) and to evaluate the correlation between the parameters and the histological grades. Sixty-two patients with surgically confirmed HCCs underwent diffusion-weighted magnetic resonance imaging with twelve b values. The differences in the ADC and D values among the groups with G1, G2, and G3 histological grades of the HCCs were statistically significant (P < 0.001). The D* and f values had no significant differences among the different histological grades of the HCCs (P > 0.05). A significant correlation was obtained between the ADC, D, and D* values and the histological grades (P < 0.05). The ROC analyses demonstrated that the D and ADC values had better diagnostic performances in differentiating low-grade HCCs from high-grade HCCs. These results suggested that the IVIM-DWI parameters might be useful in assessing the differentiation grades of carcinomas, which might be helpful in predicting the patient prognoses.
Citation	Zhu SC, Liu YH, Wei Y, Li LL, Dou SW, Sun TY, Shi DP. Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging for predicting histological grade of hepatocellular carcinoma: Comparison with conventional diffusion-weighted imaging. World J Gastroenterol 2018; 24(8): 929-940

Received	2017-12-21 08:23
Peer-Review Started	2017-12-21 09:57
To Make the First Decision	2018-01-04 06:04
Return for Revision	2018-01-04 09:26
Revised	2018-01-11 10:22
Second Decision	2018-01-18 11:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-01-18 15:06
Articles in Press	2018-01-18 15:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-02-05 03:41
Typeset the Manuscript	2018-02-23 10:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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