Publication Name	World Journal of Gastroenterology
Manuscript ID	37474
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Lei-Min Yu, Ke-Jia Zhao, Shuang-Shuang Wang, Xi Wang and Bin Lu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81470814 National Natural Science Foundation of China 81400594 Zhejiang Provincial Natural Science Foundation of China LQ14H160014
Corresponding Author	Bin Lu, MD, PhD, Doctor, Professor, Department of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou 310006, Zhejiang province, China. lvbin@medmail.com.cn
Key Words	Irritable bowel syndrome; Metabolite; Gas chromatography/mass spectrometry; Clostridium butyricum
Core Tip	In this study, we analyzed the key metabolites differentially excreted in the feces of control mice and mice with irritable bowel syndrome (IBS). A total of 14 differentially excreted metabolites were identified, and phenylalanine (a major metabolite induced by stress) was found to be the most relevant of these metabolites. Between the IBS group and IBS + C. butyricum group, 10 differentially excreted metabolites were identified, and pantothenate and coenzyme A (CoA) biosynthesis metabolites, as well as steroid hormone biosynthesis metabolites were found to be significantly relevant. Thus, supplementation with C. butyricum to IBS mice had beneficial effects through modulation of host metabolism.
Citation	Yu LM, Zhao KJ, Wang SS, Wang X, Lu B. Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome. World J Gastroenterol 2018; 24(8): 894-904

Received	2017-12-13 09:32
Peer-Review Started	2017-12-13 10:44
To Make the First Decision	2017-12-27 02:22
Return for Revision	2017-12-27 09:48
Revised	2018-01-12 13:09
Second Decision	2018-01-19 09:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-01-19 18:40
Articles in Press	2018-01-19 18:40
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-02-01 03:42
Typeset the Manuscript	2018-02-21 04:26

ISSN	1007-9327 (print) and 2219-2840 (online)
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