Publication Name	World Journal of Gastroenterology
Manuscript ID	37600
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Role of PTPN2/22 polymorphisms in pathophysiology of Crohn’s disease
Manuscript Source	Invited Manuscript
All Author List	Robert C Sharp, Shazia A Beg and Saleh A Naser
Funding Agency and Grant Number	Funding Agency Grant Number the Florida Legislative Grant and the Crohn’s Disease Grant Funded by the State of Florida (in part)
Corresponding Author	Saleh A Naser, PhD, Professor, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4110 Libra Drive, Orlando, FL 32816, United States. saleh.naser@ucf.edu
Key Words	Crohn’s disease; PTPN2; PTPN22; PTPN2/22; Mycobacteria; Single nucleotide polymorphisms
Core Tip	Knowledge of the pathophysiology of Crohn’s disease (CD) is vital in the development of new diagnosis techniques and treatments for the disease. Our study involves the investigation of single nucleotide polymorphisms (SNPs) in protein tyrosine phosphatase non-receptor type 2 and 22 (PTPN2/22) and their effects on susceptibility to mycobacteria species and the elevation of pro-inflammatory cytokines. Our data demonstrates that SNPs in PTPN2/22 lead to less negative regulation in T-cells and increase susceptibility to mycobacteria, thus increasing inflammation and apoptosis in intestinal tissues. Personalized treatment could be accomplished by genetic testing and antibiotic treatment for mycobacteria in CD patients.
Citation	Sharp RC, Beg SA, Naser SA. Role of PTPN2/22 polymorphisms in pathophysiology of Crohn’s disease. World J Gastroenterol 2018; 24(6): 657-670

Received	2017-12-20 17:32
Peer-Review Started	2017-12-21 02:43
To Make the First Decision	2017-12-27 01:53
Return for Revision	2017-12-27 03:12
Revised	2018-01-03 16:40
Second Decision	2018-01-18 11:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-01-18 15:07
Articles in Press	2018-01-18 15:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-01-31 10:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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