Publication Name	World Journal of Gastroenterology
Manuscript ID	37638
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Hong-Hui Wang, Ying He, Hong-Xian Wang, Cheng-Ling Liao, Yu Peng, Li-Jian Tao, Wei Zhang and Hui-Xiang Yang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81370547 National Natural Science Foundation of China 81400642
Corresponding Author	Hui-Xiang Yang, MD, PhD, Professor, Department of Gastroenterology, Xiangya Hospital, Central South University,, 87 Xiangya Road,, Changsha 410008, Hunan Province, China. yang_hx430@csu.edu.cn
Key Words	NUDT15; TPMT; Azathioprine; Leukopenia; Inflammatory bowel disease; Individualized therapy
Core Tip	Azathioprine (AZA) plays an important role in the remission maintenance therapy of inflammatory bowel disease (IBD). However, serious drug adverse reactions, especially leukopenia, limit its clinical application. European consensus has identified TPMT polymorphism as a predictor of AZA-induced leukopenia. However, the predictive value of TPMT is controversial in Asians with low mutation rate and effectiveness. NUDT15 polymorphism has recently been found to be strongly associated with AZA-induced leukopenia in Asians but there are few data in Chinese populations. This study aimed to observe TPMT and NUDT15 polymorphisms and compare their predictive value for AZA-induced leukopenia in Chinese IBD patients.
Citation	Wang HH, He Y, Wang HX, Liao CL, Peng Y, Tao LJ, Zhang W, Yang HX. Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease. World J Gastroenterol 2018; 24(8): 941-948

Received	2017-12-24 07:10
Peer-Review Started	2017-12-25 01:31
To Make the First Decision	2018-01-04 06:11
Return for Revision	2018-01-04 09:39
Revised	2018-01-15 03:14
Second Decision	2018-01-18 11:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-01-18 15:04
Articles in Press	2018-01-18 15:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-01-30 20:43
Typeset the Manuscript	2018-02-21 04:26

ISSN	1007-9327 (print) and 2219-2840 (online)
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