Publication Name	World Journal of Gastroenterology
Manuscript ID	38048
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease
Manuscript Source	Unsolicited Manuscript
All Author List	Neera Gupta, Robert H Lustig, Cewin Chao, Eric Vittinghoff, Howard Andrews and Cheng-Shiun Leu
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health DK077734 Children’s Digestive Health and Nutrition Foundation (now known as North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Foundation)/Crohn’s and Colitis Foundation of America (now known as Crohn’s and Colitis Foundation) Award for New Investigators CDHNF-06-002 (NG) Crohn’s and Colitis Foundation of America (now known as Crohn’s and Colitis Foundation) Career Development Award Award ID 1743 (NG) University of California San Francisco Department of Pediatrics Pediatric Clinical Research Center Clinical Research Pilot Funding Award (NG), and National Institutes of Health/National Center for Research Resources University of California San Francisco-Clinical and Translational Science Institute UL1 RR024131
Corresponding Author	Neera Gupta, MD, Associate Professor, Division of Gastroenterology and Nutrition, Department of Pediatrics, Weill Cornell Medicine, Weill Cornell Medicine, 505 East 70th Street, Helmsley Tower, 3rd Floor, New York, NY 10021, United States. neg9020@med.cornell.edu
Key Words	Inflammatory bowel disease; Azathioprine/6-mercaptopurine; Biologics; Nutrition
Core Tip	Azathioprine/6-mercaptopurine were negatively associated with specific anthropometric parameters, suggesting a possible negative effect vs poor efficacy of thiopurines in pediatric Crohn’s disease (CD). Infliximab was positively associated with standardized height in females only, suggesting a possible sex difference in response to infliximab from the standpoint of statural growth in pediatric CD. Specific serum biomarkers were associated with standardized height in males only, supporting that inflammation has a more detrimental effect on statural growth in males with pediatric CD.
Citation	Gupta N, Lustig RH, Chao C, Vittinghoff E, Andrews H, Leu CS. Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease. World J Gastroenterol 2018; 24(18): 2036-2046

Received	2018-02-03 02:16
Peer-Review Started	2018-02-03 12:42
To Make the First Decision	2018-02-24 00:42
Return for Revision	2018-02-24 03:01
Revised	2018-04-12 10:59
Second Decision	2018-04-25 10:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-04-26 02:17
Articles in Press	2018-04-26 02:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-05-10 08:52

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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