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6/9/2018 4:35:42 AM | Browse: 351 | Download: 189
Publication Name World Journal of Gastroenterology
Manuscript ID 38094
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway
Manuscript Source Unsolicited Manuscript
All Author List Yue Lu, Leng Li, Jin-Wei Zhang, Xiao-Qin Zhong, Jian-An Wei and Ling Han
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81202635
Guangdong Provincial Bureau of Chinese Medicine 20151244
Corresponding Author Ling Han, PhD, Research Scientist, The Second Clinical College, Guangzhou University of Chinese Medicine, Inner ring western road, University Town, Guangzhou 510006, Guangdong Province, China. linghan99@gzucm.edu.cn
Key Words Inflammatory bowel disease; tight junction; total polysaccharides of the Sijunzi decoction; Nuclear factor-κB pathway
Core Tip Total polysaccharides of the Sijunzi decoction (TPSJ) comprise the active ingredient of Sijunzi decoction, which has long been used to treat gastrointestinal tract disorders. However, the mechanisms by which TPSJ af­fects the intestinal epithelial barrier remain unclear. Our study results demonstrated that TPSJ attenuated tumor necrosis factor (TNF)-α-induced intestinal barrier dys­function in a Caco-2 cell monolayer. Furthermore, TPSJ inhibited TNF-α-induced upregulation of myosin light chain (MLC) phosphorylation, which is mediated by MLC kinase and NF-κB, suggesting that this mechanism might underlie the protective effects of TPSJ against intestinal epithelial barrier dysfunction triggered by proinflammatory cytokines.
Citation Lu Y, Li L, Zhang JW, Zhong XQ, Wei JA, Han L. Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway. World J Gastroenterol 2018; 24(26): 2867-2877
Received
2018-03-29 07:18
Peer-Review Started
2018-03-30 07:06
To Make the First Decision
2018-05-17 03:14
Return for Revision
2018-05-21 02:45
Revised
2018-05-25 09:15
Second Decision
2018-06-08 08:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-09 04:35
Articles in Press
2018-06-09 04:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-06-19 20:01
Typeset the Manuscript
2018-07-09 07:53
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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