Publication Name	World Journal of Nephrology
Manuscript ID	38247
Country	Italy

Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Antineutrophil cytoplasmic antibody associated vasculitides with renal involvement: Open challenges in the remission induction therapy
Manuscript Source	Invited Manuscript
All Author List	Maurizio Salvadori and Aris Tsalouchos
Funding Agency and Grant Number
Corresponding Author	Maurizio Salvadori, MD, Professor, Department of Nephrology and Renal Transplantation, Careggi University Hospital, viale Pieraccini 18, Florence 50139, Italy. maurizio.salvadori1@gmail.com
Key Words	Rapidly progressive glomerulonephritis; Remission induction therapy; Antineutrophil cytoplasmic antibody associated vasculitides; Cyclophosphamide; Rituximab; Corticosteroids; Plasma exchange; Avacopan
Core Tip	Antineutrophil cytoplasmic antibody (ANCA) associated vasculitides with renal involvement, presents as Rapidly Progressive Glomerulonephritis, are organ-threatening and potentially life-threatening diseases. Although remission induction immunosuppressive regimens overall have been very successful in the treatment of these conditions, many questions remain unanswered. The still open challenges and questions concern: (1) The choice of the first-line therapy (cyclophosphamide versus rituximab) based on renal function at baseline, new versus relapsed disease, ANCA specificity, tissue injury and safety; (2) the role of plasma exchange in combination with steroid and non steroid agents and (3) the advent of novel target therapies and strategies.
Citation	Salvadori M, Tsalouchos A. Antineutrophil cytoplasmic antibody associated vasculitides with renal involvement: Open challenges in the remission induction therapy. World J Nephrol 2018; 7(3): 71-83

Received	2018-02-02 22:47
Peer-Review Started	2018-02-05 01:45
To Make the First Decision	2018-03-02 00:26
Return for Revision	2018-03-07 08:08
Revised	2018-03-12 17:45
Second Decision	2018-04-19 00:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-04-22 17:43
Articles in Press	2018-04-22 17:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-04-29 04:49

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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