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Publication Name World Journal of Gastroenterology
Manuscript ID 38580
Country/Territory Brazil
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice
Manuscript Source Unsolicited Manuscript
All Author List Maria Carolina S Mendes, Daiane SM Paulino, Sandra R Brambilla, Juliana A Camargo, Gabriela F Persinoti and José Barreto Campello Carvalheira
Funding Agency and Grant Number
Funding Agency Grant Number
São Paulo Research Foundation 07607-8/2013
National Research Council 150127/2016-2
National Research Council 306821/2010-9
Corresponding Author José Barreto Campello Carvalheira, MD, PhD, Associate Professor, Internal Medicine - Division of oncology, UNICAMP, Tessália Vieira Camargo, S/N, Campinas 13083-970, Sao Paulo, Brazil. jbcc@g.unicamp.br
Key Words Intestinal microbiota; Chemoprevention; Lactobacillus acidophilus; Lactobacillus rhamnosus; Bifidobacterium bifidum
Core Tip Intestinal microbiota has an essential role in carcinogenesis, acting in promotion of inflammation, proliferation and neoplastic progression. Probiotic supplementation is an alternative means of favourably modulating the intestinal microbiota. In this study, we investigate the effect of supplementation with a Lactobacillus acidophilus, Lactobacillus rhamnosus and Bifidobacterium bifidum mixture during the development of an experimental model of colitis-associated colon cancer. Probiotic supplementation on colorectal cancer changed the microbiota and reduced inflammation in the colon, probably by regulating the inflammatory response, and reducing inflammatory cell infiltration by lowering chemokine expression, thus preventing colitis.
Citation Mendes MC, Paulino DS, Brambilla SR, Camargo JA, Persinoti GF, Carvalheira JB. Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice. World J Gastroenterol 2018; 24(18): 1995-2008
Received
2018-03-07 01:36
Peer-Review Started
2018-03-07 06:10
To Make the First Decision
2018-04-03 00:59
Return for Revision
2018-04-06 09:04
Revised
2018-04-13 21:15
Second Decision
2018-04-23 05:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-04-23 16:36
Articles in Press
2018-04-23 16:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-05-10 08:53
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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