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4/23/2018 4:32:17 PM | Browse: 304 | Download: 317
Publication Name World Journal of Gastroenterology
Manuscript ID 38796
Country/Territory Romania
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title New therapeutic options opened by the molecular classification of gastric cancer
Manuscript Source Invited Manuscript
All Author List Mihaela Chivu-Economescu, Lilia Matei, Laura Georgiana Necula, Denisa Laura Dragu, Coralia Bleotu and Carmen Cristina Diaconu
Funding Agency and Grant Number
Corresponding Author Mihaela Chivu-Economescu, PhD, Senior Researcher, Department of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave, Bucharest 030304, Romania. mihaela.economescu@virology.ro
Key Words Gastric cancer; Molecular classification; Immunotherapy; Targeted therapy; Clinical trials
Core Tip A new molecular classification of gastric cancer (GC) became available after publication of three landmark studies: The Cancer Genome Atlas, “Singapore-Duke” study, and Asian Cancer Research Group, allowing patient selection for specific targeted therapy. The Epstein-Barr virus positive, microsatellite stable TP53-active or microsatellite-unstable tumors subtypes presents tumour infiltrating patterns with overexpression of PD-1, PD-L1, PDL-2. Preliminary data show high response rate to immunotherapy and open new avenues to gene therapy. Currently effective therapies for diffuse GC are lacking. Mutations in e-cadherin and Ras homolog family member A genes, or Claudin-18-ARHGAP6/26 fusions may be exploited as therapeutic targets. The only targeted therapies approved so far for chromosomal instability and microsatellite stable TP53-inactive subtypes of GC are trastuzumab and ramucirumab (HER2 and VEGFR2 inhibitors).
Citation Chivu-Economescu M, Matei L, Necula LG, Dragu DL, Bleotu C, Diaconu CC. New therapeutic options opened by the molecular classification of gastric cancer. World J Gastroenterol 2018; 24(18): 1942-1961
Received
2018-03-20 02:44
Peer-Review Started
2018-03-20 07:29
To Make the First Decision
2018-04-03 00:53
Return for Revision
2018-04-10 11:26
Revised
2018-04-12 10:35
Second Decision
2018-04-23 05:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-04-23 16:32
Articles in Press
2018-04-23 16:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-05-10 08:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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