Publication Name	World Journal of Diabetes
Manuscript ID	39070
Country	India

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Role of bisphosphonates in the management of acute Charcot foot
Manuscript Source	Invited Manuscript
All Author List	Harsh Durgia, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Rajan Palui, Kalyani Sridharan and Henith Raj
Funding Agency and Grant Number
Corresponding Author	Jayaprakash Sahoo, Associate Professor, Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Room No. 5444, 4th floor, Superspeciality Block, Pondicherry 605006, India. jppgi@yahoo.com
Key Words	Charcot foot; Diabetes mellitus; Charcot neuroarthropathy; Bisphosphonates; Pamidronate
Core Tip	Bisphosphonate is an attractive treatment option for acute Charcot foot. This is based on the fa­ct that increased osteoclastic activity plays a central role in the pathogenesis of acute Charcot foot. Among bisphosphonates, the maximum evidence in the lite­rature is available for pamidronate. It has been shown to reduce the markers of Charcot foot activity, like rai­sed skin temperature, pain, and edema. However, the quality of evidence is low. They should be used along with immobilization and offloading. The side effects of bisphosphonates and their contra-indications for use should be kept in mind while treating these patients with them.
Citation	Durgia H, Sahoo J, Kamalanathan S, Palui R, Sridharan K, Raj H. Role of bisphosphonates in the management of acute Charcot foot. World J Diabetes 2018; 9(7): 115-126

Received	2018-03-29 09:11
Peer-Review Started	2018-03-29 09:50
To Make the First Decision	2018-04-23 05:46
Return for Revision	2018-04-24 05:16
Revised	2018-04-26 18:42
Second Decision	2018-06-12 09:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-14 05:49
Articles in Press	2018-06-14 05:49
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-06-18 00:43
Typeset the Manuscript	2018-07-07 06:57

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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