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6/16/2018 6:06:54 AM | Browse: 305 | Download: 336
Publication Name World Journal of Gastroenterology
Manuscript ID 39107
Country/Territory New Zealand
Category Immunology
Manuscript Type Minireviews
Article Title Multiparametric analysis of colorectal cancer immune responses
Manuscript Source Invited Manuscript
All Author List Julia K H Leman, Sarah K Sandford, Janet L Rhodes and Roslyn A Kemp
Funding Agency and Grant Number
Corresponding Author Roslyn A Kemp, PhD, Associate Professor, Microbiology and Immunology, University of Otago, PO Box 56, 720 Cumberland St, Dunedin 9010, New Zealand. roslyn.kemp@otago.ac.nz
Key Words Colorectal cancer; Flow cytometry; Immune cells; Multiparametric analysis; Immunohistochemistry; Mass cytometry; Microscopy
Core Tip Colorectal cancer (CRC) is a heterogeneous disease. The immune response to CRC is highly variable, clinically relevant, and as yet poorly characterised. Clinical management of this disease is still relatively uniform, and does not yet accommodate the influence of immune response on patient outcomes. Multiparametric analysis of CRC is the best approach to describe the immune response. Improved understanding of immune responses to CRC will guide patient management, improved survival, and identify new potential therapeutic biomarkers. This review summarises currently available modes of multiparametric analysis, their advantages and drawbacks, and their clinical relevance.
Citation Leman JK, Sandford SK, Rhodes JL, Kemp RA. Multiparametric analysis of colorectal cancer immune responses. World J Gastroenterol 2018; 24(27): 2995-3005
Received
2018-03-29 04:08
Peer-Review Started
2018-03-29 09:55
To Make the First Decision
2018-05-09 04:16
Return for Revision
2018-05-16 10:21
Revised
2018-05-23 23:50
Second Decision
2018-06-15 07:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-16 06:06
Articles in Press
2018-06-16 06:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-07-18 02:47
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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