Publication Name	World Journal of Gastroenterology
Manuscript ID	39153
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effects of hepatitis E virus infection on interferon production via ISG15
Manuscript Source	Unsolicited Manuscript
All Author List	Min Wang, Ying Huang, Man He, Wen-Ju Peng and De-Ying Tian
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 81570540
Corresponding Author	De-Ying Tian, PhD, Professor, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430030, Hubei Provice, China. dytian@tjh.tjmu.edu.cn
Key Words	Open reading frame 3; Interferon-stimulated gene 15; Interferon-alpha; Hepatitis E virus; Interferon-beta
Core Tip	To date, few studies have investigated the role of ISG15 in hepatitis E virus (HEV) infection and the impact of ISG15 on interferons (IFN) production. This study showed that HEV could inhibit the level of type Ⅰ IFN through regulating the expression of IFN-stimulated gene (ISG)15, which may attenuate the IFN response, allowing for successful infection of their hosts. The present study enhances the understanding of the interaction between ISG15 and HEV in the host innate immune response, which may provide useful insight for the development of new antiviral drugs and antiviral strategies.
Citation	Wang M, Huang Y, He M, Peng WJ, Tian DY. Effects of hepatitis E virus infection on interferon production via ISG15. World J Gastroenterol 2018; 24(20): 2173-2180

Received	2018-03-29 10:16
Peer-Review Started	2018-03-30 08:15
To Make the First Decision	2018-04-11 07:18
Return for Revision	2018-04-13 07:34
Revised	2018-04-19 13:06
Second Decision	2018-04-23 05:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-04-23 16:29
Articles in Press	2018-04-23 16:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-05-14 21:29
Typeset the Manuscript	2018-05-17 01:03

ISSN	1007-9327 (print) and 2219-2840 (online)
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