Publication Name	World Journal of Gastroenterology
Manuscript ID	39250
Country	Germany

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells
Manuscript Source	Unsolicited Manuscript
All Author List	Franz-Tassilo Müller-Graff, Brit Fitzner, Robert Jaster, Brigitte Vollmar and Dietmar Zechner
Funding Agency and Grant Number	Funding Agency Grant Number Deutsche Forschungsgemeinschaft (DFG research group FOR 2591) No. 321137804, ZE 712/1-1 and VO 450/15-1
Corresponding Author	Dietmar Zechner, PhD, Academic Research, Senior Scientist, Institute for Experimental Surgery, Rostock University Medical Center, Schillingallee 69a, Rostock 18057, Germany. dietmar.zechner@uni-rostock.de
Key Words	Autoimmune disease; Diabetes; Treg; FoxP3; Autoimmune pancreatitis; MRL/MpJ mice
Core Tip	Temporary or sustained hyperglycemia can be observed in about 42%-66% of patients with auto­immune pancreatitis. However, it is unknown to what extent hyperglycemia has an influence on the course of this disease. This preclinical study demonstrates that hyperglycemia does not lead to an aggravation but rather an attenuation of autoimmune pancreatitis. Thus, this result might have the clinical implication that a tight adjust­ment of blood glucose concentration in patients with autoimmune pancreatitis is not needed, because it might not have a beneficial effect on the progression of this disease.
Citation	Müller-Graff FT, Fitzner B, Jaster R, Vollmar B, Zechner D. Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells. World J Gastroenterol 2018; 24(28): 3120-3129

Received	2018-04-17 00:31
Peer-Review Started	2018-04-17 16:26
To Make the First Decision	2018-05-23 06:12
Return for Revision	2018-06-11 09:00
Revised	2018-06-17 08:14
Second Decision	2018-06-27 09:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-27 17:30
Articles in Press	2018-06-27 17:30
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-07-07 17:31
Typeset the Manuscript	2018-07-25 03:14

ISSN	1007-9327 (print) and 2219-2840 (online)
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