BPG is committed to discovery and dissemination of knowledge
Articles in Press
7/16/2018 1:51:42 AM | Browse: 441 | Download: 261
Publication Name World Journal of Gastroenterology
Manuscript ID 39571
Country/Territory China
Category Oncology
Manuscript Type Review
Article Title Drug resistance and new therapies in colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Kevin Van der Jeught, Han-Chen Xu, Yu-Jing Li, Xiong-Bin Lu and Guang Ji
Funding Agency and Grant Number
Funding Agency Grant Number
NSFC 81620108030
NIH CA203737
Corresponding Author Guang Ji, MD, PhD, Chief Doctor, Professor, Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. jiliver@vip.sina.com
Key Words Colorectal cancer; Therapy resistance; Antibody-drug conjugates; α-amanitin; Tumor micro­environment; Immunotherapy; Checkpoint inhibitors; Microbiome
Core Tip Therapy resistance has been a culprit for colorectal cancer (CRC) treatment. Here, we review a novel therapeutic approach using α-amanitin antibody-drug conjugates inhibiting RNA polymerase Ⅱ against CRC with hemizygous loss of p53. Since its mechanism of cell killing is independent of the generally used tubulin inhibitors and chemotherapy drugs, this approach shows the promise to overcome common drug resistance. In addition, we summarize the sensitivity of CRC to newly developed immune checkpoint inhibitors. While patients with microsatellite instability-high CRC remain the sole subgroup responsive to current checkpoint inhibitors so far, we highlight potentially new developments that may lead to promising results in treating patients with microsatellite-stable CRC, which constitutes the majority of this disease.
Citation Van der Jeught K, Xu HC, Li YJ, Lu XB, Ji G. Drug resistance and new therapies in colorectal cancer. World J Gastroenterol 2018; 24(34): 3834-3848
Received
2018-04-27 09:00
Peer-Review Started
2018-04-27 09:45
To Make the First Decision
2018-05-30 00:21
Return for Revision
2018-06-11 08:51
Revised
2018-06-25 12:11
Second Decision
2018-07-13 07:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-07-16 01:51
Articles in Press
2018-07-16 01:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-07-21 23:11
Typeset the Manuscript
2018-09-05 07:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com