Publication Name	World Journal of Hepatology
Manuscript ID	39591
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Acute liver failure secondary to severe systemic disease from fatal hemophagocytic lymphohistiocytosis: Case report and systematic literature review
Manuscript Source	Invited Manuscript
All Author List	Mitchell S Cappell, Ismail Hader and Mitual Amin
Funding Agency and Grant Number
Corresponding Author	Mitchell S Cappell, FACG, MD, PhD, Attending Doctor, Chief Doctor, Professor, Division of Gastroenterology and Hepatology, William Beaumont Hospital, MOB #602, 3535 W. Thirteen Mile Rd., Royal Oak, MI 48073, United States. mitchell.cappell@beaumont.edu
Key Words	Hemophagocytic lymphohistiocytosis; Acute liver failure; Liver injury; Liver transplantation; Acquired immune hyperactivation; Pancytopenia
Core Tip	This work systematically reviews liver disease in hemophagocytic lymphohistiocytosis (HLH), proposes contraindications for liver-transplantation in such pati­ents, and reports an illustrative case. A 47-year-old-man was hospitalized with high-grade pyrexia, total-bilirubin = 45 g/dL, and profound neutropenia. Bone marrow biopsy/aspirate revealed hemophagocytic his­tiocytes. The patient had HLH, satisfying 6 Histiocytic Society criteria. Liver-biopsy histopathology revealed relatively well-preserved hepatic parenchyma, except for sparse hepatocytic necrosis. The patient was not a liver-transplant-candidate, despite model for end stage liver disease-score = 33, due to multi-organ failure from HLH. He expired from multi-organ failure despite receiving corticosteroids. This case and systematic review reveals patients with HLH may not be liver tra­nsplant candidates because of liver failure from mul­tisystem failure.
Citation	Cappell MS, Hader I, Amin M. Acute liver failure secondary to severe systemic disease from fatal hemophagocytic lymp­hohistiocytosis: Case report and systematic literature review. World J Hepatol 2018; 10(9): 629-636

Received	2018-04-28 01:06
Peer-Review Started	2018-05-03 01:58
To Make the First Decision	2018-05-24 23:53
Return for Revision	2018-05-25 07:45
Revised	2018-07-20 23:03
Second Decision	2018-08-28 10:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-08-28 15:57
Articles in Press	2018-08-28 15:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-09-26 00:20

ISSN	1948-5182 (online)
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