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Publication Name World Journal of Gastroenterology
Manuscript ID 39634
Country Spain
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications
Manuscript Source Invited Manuscript
All Author List Javier A García-Vilas and Miguel Ángel Medina
Funding Agency and Grant Number
Funding Agency Grant Number
MINECO and FEDER BIO2014-56092-R
Andalusian Government and FEDER P12-CTS-1507
Andalusian Government BIO-267
Corresponding Author Miguel Ángel Medina, PhD, Full Professor, Department of Molecular Biology and Biochemistry, University of Málaga, Department of Molecular Biology and Biochemistry Faculty of Sciences, University of Malaga , Boulevar Louis Pasteur 31, Málaga 29071, Spain. medina@uma.es
Key Words Hepatocellular carcinoma; Hepatocyte growth factor/c-MET; Tumor microenvironment; c-Met canonical and non-canonical pathways
Core Tip Hepatocellular carcinoma (HCC) is a tumor usually arising from previous hepatic diseases as cirrhosis and chronic hepatitis B and C infections. Several studies have shown that a key factor for HCC oncogenesis is chronic inflammation. Inflammation induces changes in the gene expression pattern in surrounding cells. These changes provide an environment with a high level of cytokines, promoting hepatocyte transforma­tion to tumor cells. New therapies against HCC are focused on regulating stromal cells within the tumor microenvironment to avoid HCC progression.
Citation García-Vilas JA, Medina MÁ. Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications. World J Gastroenterol 2018; 24(33): 3695-3708
Received
2018-05-03 10:32
Peer-Review Started
2018-05-04 06:47
To Make the First Decision
2018-05-17 02:55
Return for Revision
2018-05-21 07:51
Revised
2018-06-28 19:13
Second Decision
2018-07-13 09:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-07-16 01:50
Articles in Press
2018-07-16 01:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-08-31 09:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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