Publication Name	World Journal of Nephrology
Manuscript ID	39724
Country	Ireland

Category	Urology & Nephrology
Manuscript Type	Minireviews
Article Title	Oral alkali therapy and the management of metabolic acidosis of chronic kidney disease: a narrative literature review
Manuscript Source	Unsolicited Manuscript
All Author List	Adeel Rafi Ahmed and David Lappin
Funding Agency and Grant Number
Corresponding Author	Adeel Rafi Ahmed, MBChB, MRCP, Staff Physician, Department of Nephrology, University Hospital Galway, Newcastle Road, Galway H91YR1, Ireland. adeel.r.ahmed@gmail.com
Key Words	Chronic metabolic acidosis; Chronic kidney disease; Oral sodium bicarbonate; Oral alkali therapy; Health economics; Serum bicarbonate
Core Tip	Chronic metabolic acidosis contributes to the progression of chronic kidney disease (CKD). We summarise and analyse current evidence regarding the management of the metabolic acidosis of CKD, as well as the potential benefits and adverse effects. We also offer novel therapeutic guidelines for clinicians, which include the most evidence-based range to maintain serum bicarbonate in the CKD patient population.
Citation	Ahmed AR, Lappin D. Oral alkali therapy and the management of metabolic acidosis of chronic kidney disease: A narrative literature review. World J Nephrol 2018; 7(6): 117-122

Received	2018-05-07 00:33
Peer-Review Started	2018-05-07 01:51
To Make the First Decision	2018-05-24 23:53
Return for Revision	2018-05-25 07:45
Revised	2018-08-05 19:04
Second Decision	2018-08-30 08:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-08-30 17:43
Articles in Press	2018-08-30 17:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-09-09 01:40
Typeset the Manuscript	2018-10-10 01:51

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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