Publication Name	World Journal of Gastroenterology
Manuscript ID	39862
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients
Manuscript Source	Invited Manuscript
All Author List	Bettina M Buchholz, Panagis M Lykoudis, Reena Ravikumar, Joerg M Pollok and Giuseppe Kito Fusai
Funding Agency and Grant Number
Corresponding Author	Giuseppe Kito Fusai, FRCS (Gen Surg), MSc, Surgeon, Department of HPB Surgery and Liver Transplantation, Royal Free Hospital, Pond Street, London NW32QG, United Kingdom. g.fusai@ucl.ac.uk
Key Words	Recurrent primary sclerosing cholangitis; Risk factor; Ulcerative colitis; Colectomy; Liver transplantation
Core Tip	There are no known treatments that can alter the development and/or progression of recurrent primary sclerosing cholangitis (rPSC) after liver transplantation (LT). Shared leukocyte recruitment pathways of the gut-liver axis, bacterial translocation into the portal circulation from an inflamed gut and intestinal dysbiosis might contribute to the pathogenesis of rPSC. Indeed, inflammatory bowel dis­ease, ulcerative colitis and in particular active colitis post-LT significantly increase the risk of rPSC and the available data favours a protective role of pre-/peri-LT co­lectomy in rPSC. Prospective studies and randomized trials are needed to further elucidate a possible mechanistic link between retained colon and rPSC.
Citation	Buchholz BM, Lykoudis PM, Ravikumar R, Pollok JM, Fusai GK. Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients. World J Gastroenterol 2018; 24(28): 3171-3180

Received	2018-05-16 01:30
Peer-Review Started	2018-05-16 11:15
To Make the First Decision	2018-06-06 02:16
Return for Revision	2018-06-11 08:00
Revised	2018-07-08 11:17
Second Decision	2018-07-13 09:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-07-16 01:48
Articles in Press	2018-07-16 01:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-07-25 03:16

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
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