Publication Name	World Journal of Gastroenterology
Manuscript ID	39934
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	C-peptide as a key risk factor for non-alcoholic fatty liver disease in the United States population
Manuscript Source	Unsolicited Manuscript
All Author List	Amporn Atsawarungruangkit, Jirat Chenbhanich and George Dickstein
Funding Agency and Grant Number
Corresponding Author	Amporn Atsawarungruangkit, BPharm, MD, Doctor, Research Fellow, Department of Medicine, MetroWest Medical Center, 115 Lincoln St., Framingham, MA 01702, United States. a.atsawarungruangkit@mwmc.com
Key Words	Insulin resistance; Fatty liver; Hepatosteatosis; Metabolic syndrome; C-peptide
Core Tip	Non-alcoholic fatty liver disease (NAFLD) is a growing global epidemic and associated with many conditions and factors, including insulin resistance. How­ever, C-peptide has not been used in practice to assess insulin resistance in NAFLD patients. Using a large national dataset, we demonstrated that three most important risk factors for NAFLD are waist circumference, fasting C-peptide, and alanine aminotransferase, respectively. Such results revealed that C-peptide superior to measure­ment of fasting insulin levels and can potentially be used for screening or monitoring the degree of insulin resistance in NAFLD.
Citation	Atsawarungruangkit A, Chenbhanich J, Dickstein G. C-peptide as a key risk factor for non-alcoholic fatty liver disease in the United States population. World J Gastroenterol 2018; 24(32): 3663-3670

Received	2018-05-31 01:17
Peer-Review Started	2018-05-31 02:58
To Make the First Decision	2018-06-21 00:56
Return for Revision	2018-07-04 08:31
Revised	2018-07-06 01:33
Second Decision	2018-07-13 08:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-07-16 01:38
Articles in Press	2018-07-16 01:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-08-27 01:40

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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