Publication Name	World Journal of Gastroenterology
Manuscript ID	39970
Country	Taiwan

Category	Oncology
Manuscript Type	Basic Study
Article Title	Metabolomic alterations and chromosomal instability status in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng-Kun Tsai, Ta-Sen Yeh, Ren-Chin Wu, Ying-Chieh Lai, Meng-Han Chiang, Kuan-Ying Lu, Cheng-Yu Hung, Hung-Yao Ho, Mei-Ling Cheng and Gigin Lin
Funding Agency and Grant Number	Funding Agency Grant Number the Chang Gung Foundation CMRPG3E1321-2 the Chang Gung Foundation IRB201601916B0, IRB103-7448B the Ministry of Science and Technology Taiwan MOST 106-2314-B-182A-019-MY3
Corresponding Author	Gigin Lin, MD, PhD, Associate Professor, Department of Medical Imaging and Intervention, Imaging Core Lab, Institute for Radiological Research,, Chang Gung Memorial Hospital at Linkou and Chang Gung University, No.5, Fuxing St., Guishan Dist., Taoyuan 333, Taiwan. giginlin@gmail.com
Key Words	Gastric cancer; Metabolomics; Oncogene; Copy-number; Chromosomal instability; Liquid chro­matography-mass spectrometry
Core Tip	We studied the correlation of the compre­hensive metabolomic profiles of gastric cancer with its chromosomal instability (CIN) status. In this disease landscape study with no pre-specified hypothesis, we combined a gene molecule classification method with a metabolomics method to discover metabolic information for accurate tumor classification. CIN status-based metabolomic profiling has demonstrated translational potential in biomarker discovery and novel therapeutics development.
Citation	Tsai CK, Yeh TS, Wu RC, Lai YC, Chiang MH, Lu KY, Hung CY, Ho HY, Cheng ML, Lin G. Metabolomic alterations and chromosomal instability status in gastric cancer. World J Gastroenterol 2018; 24(33): 3760-3769

Received	2018-05-22 11:07
Peer-Review Started	2018-05-23 07:49
To Make the First Decision	2018-06-13 06:12
Return for Revision	2018-06-15 07:31
Revised	2018-06-27 10:32
Second Decision	2018-07-13 08:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-07-16 01:42
Articles in Press	2018-07-16 01:42
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-07-19 18:35
Typeset the Manuscript	2018-08-31 09:13

ISSN	1007-9327 (print) and 2219-2840 (online)
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