Publication Name	World Journal of Gastroenterology
Manuscript ID	39984
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Antiangiogenic therapy for portal hypertension in liver cirrhosis: Current progress and perspectives
Manuscript Source	Invited Manuscript
All Author List	Dmitry Victorovich Garbuzenko, Nikolay Olegovich Arefyev and Evgeniy Leonidovich Kazachkov
Funding Agency and Grant Number	Funding Agency Grant Number RFBR 18-315-00434
Corresponding Author	Dmitry Victorovich Garbuzenko, MD, PhD, Professor, Department of Faculty Surgery, South Ural State Medical University, Box 12317, Chelyabinsk 454080, Russia. garb@inbox.ru
Key Words	Liver cirrhosis; Portal hypertension; Patho­genesis; Angiogenesis; Antiangiogenic therapy
Core Tip	This review describes the role of angiogenesis in the pathogenesis of portal hypertension in liver cirrhosis and the prospects of antiangiogenic therapy. The analysis of the data showed that angiogenesis plays an important role in the pathogenesis of cirrhosis and accompanies portal hypertension, underlying its development and causing related complications. Although most of angiogenesis inhibitors were studied only in animal experiments, this selective therapy for abnormally growing newly formed vessels is patho­genetically reasonable to treat portal hypertension and associated complications.
Citation	Garbuzenko DV, Arefyev NO, Kazachkov EL. Antiangiogenic therapy for portal hypertension in liver cirrhosis: Current progress and perspectives. World J Gastroenterol 2018; 24(33): 3738-3748

Received	2018-05-27 05:27
Peer-Review Started	2018-05-27 09:57
To Make the First Decision	2018-07-04 01:26
Return for Revision	2018-07-06 06:57
Revised	2018-07-09 07:25
Second Decision	2018-07-13 08:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-07-16 01:38
Articles in Press	2018-07-16 01:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-08-31 09:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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