Publication Name	World Journal of Clinical Cases
Manuscript ID	40191
Country	United States

Category	Oncology
Manuscript Type	Review
Article Title	Cancer and comorbidity: The role of leptin in breast cancer and associated pathologies
Manuscript Source	Invited Manuscript
All Author List	Amitabha Ray
Funding Agency and Grant Number
Corresponding Author	Amitabha Ray, MBBS, MD, PhD, Associate Professor, Lake Erie College of Osteopathic Medicine, Seton Hill University, 20 Seton Hill Drive, Greensburg, PA 15601, United States. aray@lecom.edu
Key Words	Hypertension; Obesity; Postmenopausal breast cancer; Comorbidity; Diabetes
Core Tip	Obesity and associated pathologies such as insulin resistance and metabolic syndrome are inter­related health disorders wherein a chronic low-grade inflammation persists. Perhaps this inflammatory con­dition is associated with the etiology and disease course of postmenopausal breast cancer, like other obe­sity-related diseases such as type-2 diabetes mellitus and hypertension. Often these diseases may coexist, and comorbidity worsens the prognosis of cancer patients. Leptin is an important adipokine (mainly released by fat cells), which may play a crucial role in these obesity-related diseases.
Citation	Ray A. Cancer and comorbidity: The role of leptin in breast cancer and associated pathologies. World J Clin Cases 2018; 6(12): 483-492

Received	2018-06-06 01:27
Peer-Review Started	2018-06-06 03:05
To Make the First Decision	2018-08-01 03:27
Return for Revision	2018-08-03 01:54
Revised	2018-08-23 03:55
Second Decision	2018-08-30 08:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-08-30 18:57
Articles in Press	2018-08-30 18:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-09-08 20:32
Typeset the Manuscript	2018-10-23 07:35

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com