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Publication Name World Journal of Gastroenterology
Manuscript ID 40323
Country of Manuscript Source Croatia
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine
Manuscript Source Unsolicited Manuscript
All Author List Fedor Amic, Domagoj Drmic, Zdenko Bilic, Ivan Krezic, Helena Zizek, Marina Peklic, Robert Klicek, Alen Pajtak, Enio Amic, Tinka Vidovic, Mislav Rakic, Marija Milkovic Perisa, Katarina Horvat Pavlov, Antonio Kokot, Ante Tvrdeic, Alenka Boban Blagaic, Mario Zovak, Sven Seiwerth and Predrag Sikiric
Funding Agency and Grant Number
Correspondence To Predrag Sikiric, MD, PhD, Professor, Department of Pharmacology, Medical Faculty, University of Zagreb, Salata 11, POB 916, Zagreb 10000, Croatia. sikiric@mef.hr
Keywords Bypassing; Major venous occlusion; Duodenal lesions; BPC 157; L-NAME; L-arginine; Reduction of free radical formation; Rats
Core Tip Up to now, application of, prototype cytoprotective agent BPC 157 induced bypassing of occlusion, in rats underwent vessels occlusions, through rapid collaterals presentation, and lesions and whole consequent syndrome (ischemic colitis; deep vein thrombosis, Virchow triad) were attenuated. In rats underwent superior anterior pancreaticoduodenal vein-ligation, medication was with BPC 157, L-NAME; L-arginine, saline given alone and/or together at 1 min ligation time. Unlike severe course in controls, BPC 157 rats commonly exhibited strong attenuation of mucosal lesion and serosal congestion, since BPC 157 rescued original duodenal flow through inferior anterior pancreaticoduodenal vein to superior mesenteric vein flow.
Citation Amic F, Drmic D, Bilic Z, Krezic I, Zizek H, Peklic M, Klicek R, Pajtak A, Amic E, Vidovic T, Rakic M, Milkovic Perisa M, Horvat Pavlov K, Kokot A, Tvrdeic A, Boban Blagaic A, Zovak M, Seiwerth S, Sikiric P. Bypassing major venous occlusion and duodenal lesions in rat, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine. World J Gastroenterol 2018; In press
Received
2018-08-08 10:22
Peer-Review Started
2018-08-09 06:31
To Make the First Decision
2018-10-08 03:45
Return for Revision
2018-10-08 07:40
Revised
2018-11-26 20:02
Second Decision
2018-11-30 09:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-01 04:02
Articles in Press
2018-12-01 04:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma
Reviewer Code 04881496, and 02439165
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Revised Manuscript 40323-Review.docx
Peer-review Report 40323-Peer-review(s).pdf
Answering Reviewers 40323-Answering reviewers.pdf
Scientific Misconduct Check 40323-Scientific misconduct check.pdf
Scientific Editor Work List 40323-Scientific editor work list.pdf
Audio Core Tip 40323-Audio core tip.mp3
Biostatistics Review Certificate 40323-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 40323-Conflict-of-interest statement.pdf
Copyright License Agreement 40323-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 40323-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 40323-Institutional review board statement.pdf