Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	40517
Country	Japan

Category	Oncology
Manuscript Type	Basic Study
Article Title	miR-122-5p as a novel biomarker for alpha-fetoprotein-producing gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Suguru Maruyama, Shinji Furuya, Kensuke Shiraishi, Hiroki Shimizu, Hidenori Akaike, Naohiro Hosomura, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Makoto Sudo, Shingo Inoue, Hiroshi Kono and Daisuke Ichikawa
Funding Agency and Grant Number
Corresponding Author	Daisuke Ichikawa, MD, PhD, Professor, First Department of Surgery, Faculty of Medicine University of Yamanashi, 1110 Shimokato, Chuou, Yamanashi 409-3898, Japan. dichikawa@yamanashi.ac.jp
Key Words	Gastric cancer; Alpha-fetoprotein; Alpha-fetoprotein producing gastric cancer; MicroRNA; miR-122-5p
Core Tip	We examined the microRNAs (miRNA) ex­pression in alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) tissue samples using a comprehensive miRNA array-based approach, and also investigated the clinical utility of the identified AFPGC-specific miRNAs. We found the expression of miR-122-5p was significan­tly higher in the AFPGC tissues and plasma samples. Moreover, tissue miR-122-5p expression levels exhibit­ed a stronger correlation with malignant potential than plasma AFP level in AFPGC patients. miR-122-5p might be a useful biomarker for early detection and disease monitoring in AFPGC.
Citation	Maruyama S, Furuya S, Shiraishi K, Shimizu H, Akaike H, Hosomura N, Kawaguchi Y, Amemiya H, Kawaida H, Sudo M, Inoue S, Kono H, Ichikawa D. miR-122-5p as a novel biomarker for alpha-fetoprotein-producing gastric cancer. World J Gastrointest Oncol 2018; 10(10): 344-350

Received	2018-07-04 02:42
Peer-Review Started	2018-07-05 01:53
To Make the First Decision	2018-07-27 01:11
Return for Revision	2018-07-31 02:45
Revised	2018-08-05 13:06
Second Decision	2018-08-31 07:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-08-31 21:41
Articles in Press	2018-08-31 21:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-10-09 08:05

ISSN	1948-5204 (online)
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