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Publication Name World Journal of Orthopedics
Manuscript ID 40536
Country of Manuscript Source Italy
Specialty Orthopedics
Manuscript Type Systematic Review
Article Title Etiology of Legg-Calvé-Perthes disease: A systematic review
Manuscript Source Invited Manuscript
All Author List Vito Pavone, Emanuele Chisari, Andrea Vescio, Claudio Lizzio, Giuseppe Sessa and Gianluca Testa
Funding Agency and Grant Number
Correspondence To Vito Pavone, MD, PhD, Associate Professor, Department of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, University Hospital Policlinico-Vittorio Emanuele, University of Catania, Via Plebiscito 628, Catania 95100, Italy. vpavone@unict.it
Keywords Legg-Calvé-Perthes disease; Etiology; Pathogenesis; Genetics; Risk factors
Core Tip Legg-Calvé-Perthes disease is a complex disease affecting the epiphysis of the femoral head in the paediatric population. Historically considered as an osteochondrosis, it is now being referred to as an idiopathic avascular necrosis of the femoral head in the paediatric population. Despite the etiology of the disease having been widely researched, it is still not fully understood. The major hypothesis relies on a multifactorial genesis involving mechanical, genetic, and systemic conditions. Further studies are necessary to understand the complex and multifactorial genesis of the avascular necrosis characterizing the disease.
Citation Pavone V, Chisari E, Vescio A, Lizzio C, Sessa G, Testa G. Etiology of Legg-Calvé-Perthes disease: A systematic review. World J Orthop 2019; In press
Received
2018-11-02 02:32
Peer-Review Started
2018-11-02 13:54
To Make the First Decision
2018-11-29 07:47
Return for Revision
2018-12-06 06:18
Revised
2018-12-06 20:57
Second Decision
2019-01-08 11:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-10 16:37
Articles in Press
2019-01-10 16:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2218-5836 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ying Dou
Reviewer Code 02710967, and 00503623
Editorial Director Fang-Fang Ji
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Revised Manuscript 40536-Review.docx
Peer-review Report 40536-Peer-review(s).pdf
Answering Reviewers 40536-Answering reviewers.pdf
Scientific Misconduct Check 40536-Scientific misconduct check.pdf
Scientific Editor Work List 40536-Scientific editor work list.pdf
Audio Core Tip 40536-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 40536-Conflict-of-interest statement.pdf
Copyright License Agreement 40536-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 40536-Language certificate.pdf