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8/28/2018 2:51:43 PM | Browse: 539 | Download: 487
Publication Name World Journal of Clinical Cases
Manuscript ID 41140
Country China
Category Medicine, Research & Experimental
Manuscript Type Case Report
Article Title Possible connection between elevated serum -fetoprotein and placental necrosis during pregnancy: A case report and review of literature
Manuscript Source Unsolicited Manuscript
All Author List Meng-Yao Yu, Lei Xi, Jie-Xin Zhang and Shi-Chang Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81501817
National Natural Science Foundation of China 81671836
Natural Science Youth Foundation of Jiangsu Province BK20151029
Key Laboratory for Laboratory Medicine of Jiangsu Province of China ZDXKB2016005
Corresponding Author Shi-Chang Zhang, MD, PhD, Assistant Professor, Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing 210029, Jiangsu Province, China. zsc78@yeah.net
Key Words Serum α-fetoprotein; Intermittent bleeding; Necrosis; Gynecological sonography; Placenta previa
Core Tip Placental necrosis with extremely high mater¬nal serum -fetoprotein (AFP) is rare. We reported a 23-year-old female patient with central placenta previa suffered from repeated vaginal bleeding. Follow-up ultrasonography revealed a gradually enlarging hypoecho between the amniotic sac and the uterine myometrium. Until 32 wk of gestation, laboratory results showed extremely elevated maternal serum AFP. Both intraoperative exploration of the placenta and histological examination demonstrated the hypoechoic area was necrotic tissue. To our knowledge, this is the first report of a rare case of extreme AFP level in placental necrosis. Clinicians should consider the combination usage of quantitative ultrasound imaging and AFP as a practical tool for assessing placental lesions.
Citation Yu MY, Xi L, Zhang JX, Zhang SC. Possible connection between elevated serum -fetoprotein and placental necrosis during pregnancy: A case report and review of literature. World J Clin Cases 2018; 6(13): 675-678
Received
2018-07-31 02:01
Peer-Review Started
2018-07-31 09:23
To Make the First Decision
2018-08-21 01:45
Return for Revision
2018-08-22 01:33
Revised
2018-08-23 23:51
Second Decision
2018-08-28 10:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2018-08-28 14:51
Articles in Press
2018-08-28 14:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-09-06 03:34
Typeset the Manuscript
2018-10-31 07:08
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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