Publication Name	World Journal of Clinical Oncology
Manuscript ID	41249
Country	United States

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Impact of conditioning regimen on peripheral blood hematopoietic cell transplant
Manuscript Source	Unsolicited Manuscript
All Author List	Michael Burns, Anurag K Singh, Carrie C Hoefer, Yali Zhang, Paul K Wallace, George L Chen, Alexis Platek, Timothy B Winslow, Austin J Iovoli, Christopher Choi, Maureen Ross, Philip L McCarthy and Theresa Hahn
Funding Agency and Grant Number	Funding Agency Grant Number NIH/NCI P30CA16056
Corresponding Author	Anurag K Singh, MD, Attending Doctor, Professor, Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, United States. anurag.singh@roswellpark.org
Key Words	Total body radiation; Peripheral blood hematopoietic cell transplant; Total nucleated dose; Neutrophil engraftment; Graft-versus-host-disease
Core Tip	This study investigated infused hematopoietic cell doses and their interaction with conditioning regimen intensity on outcomes after peripheral blood hematopoietic cell transplant (PBHCT). Our retrospective cohort included 247 patients receiving a first, T-replete, human leukocyte antigen-matched allogeneic PBHCT. Neutrophil engraftment was significantly faster after reduced intensity total body irradiation (TBI) based conditioning [reduced intensity conditioning (RIC) + TBI] and > 4 × 106 CD34+ cells/kg infused. Overall and progression-free survival was significantly better in patients with a RIC + TBI regimen and total nucleated cell dose > 8 × 108/kg.
Citation	Burns M, Singh AK, Hoefer CC, Zhang Y, Wallace PK, Chen GL, Platek A, Winslow TB, Iovoli AJ, Choi C, Ross M, McCarthy PL, Hahn T. Impact of conditioning regimen on peripheral blood hematopoietic cell transplant. World J Clin Oncol 2019; 10(2): 86-97

Received	2018-07-30 00:56
Peer-Review Started	2018-07-30 03:04
To Make the First Decision	2018-09-03 01:49
Return for Revision	2018-09-11 01:17
Revised	2018-09-14 16:37
Second Decision	2018-12-03 01:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-12-05 04:59
Articles in Press	2018-12-05 04:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-12-22 20:46
Typeset the Manuscript	2019-02-21 09:32

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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