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Publication Name World Journal of Clinical Oncology
Manuscript ID 41249
Country of Manuscript Source United States
Specialty Oncology
Manuscript Type Retrospective Study
Article Title Impact of conditioning regimen on peripheral blood hematopoietic cell transplant
Manuscript Source Unsolicited Manuscript
All Author List Michael Burns, Anurag K Singh, Carrie C Hoefer, Yali Zhang, Paul K Wallace, George L Chen, Alexis Platek, Timothy B Winslow, Austin J Iovoli, Christopher Choi, Maureen Ross, Philip L McCarthy and Theresa Hahn
Funding Agency and Grant Number
Funding Agency Grant Number
NIH/NCI P30CA16056
Correspondence To Anurag K Singh, MD, Attending Doctor, Professor, Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY14263, United States. anurag.singh@roswellpark.org
Keywords Total body radiation; Peripheral blood hematopoietic cell transplant; Total nucleated dose; Neutrophil engraftment; Graft-versus-host-disease
Core Tip This study investigated infused hematopoietic cell doses and their interaction with conditioning regimen intensity on outcomes after peripheral blood hematopoietic cell transplant (PBHCT). Our retrospective cohort included 247 patients receiving a first, T-replete, human leukocyte antigen-matched allogeneic PBHCT. Neutrophil engraftment was significantly faster after reduced intensity total body irradiation (TBI) based conditioning [reduced intensity conditioning (RIC) + TBI] and > 4 × 106 CD34+ cells/kg infused. Overall and progression-free survival was significantly better in patients with a RIC + TBI regimen and total nucleated cell dose > 8 × 108/kg.
Citation Burns M, Singh AK, Hoefer CC, Zhang Y, Wallace PK, Chen GL, Platek A, Winslow TB, Iovoli AJ, Choi C, Ross M, McCarthy PL, Hahn T. Impact of conditioning regimen on peripheral blood hematopoietic cell transplant. World J Clin Oncol 2018; In press
Received
2018-07-30 00:56
Peer-Review Started
2018-07-30 03:04
To Make the First Decision
2018-09-03 01:49
Return for Revision
2018-09-11 01:17
Revised
2018-09-14 16:37
Second Decision
2018-12-03 01:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-05 04:59
Articles in Press
2018-12-05 04:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2218-4333 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Fang-Fang Ji
Reviewer Code 02932624, and 03086178
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Revised Manuscript 41249-Review.docx
Peer-review Report 41249-Peer-review(s).pdf
Answering Reviewers 41249-Answering reviewers.pdf
Scientific Misconduct Check 41249-Scientific misconduct check.pdf
Scientific Editor Work List 41249-Scientific editor work list.pdf
Audio Core Tip 41249-Audio core tip.wav
Biostatistics Review Certificate 41249-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 41249-Conflict-of-interest statement.pdf
Copyright License Agreement 41249-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 41249-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 41249-Institutional review board statement.pdf
Supplementary Material 41249-Supplementary material.pdf