Publication Name	World Journal of Radiology
Manuscript ID	41399
Country	Thailand

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Basic Study
Article Title	Effects of muscle fiber orientation to main magnetic field on muscle metabolite profiles for magnetic resonance spectroscopy acquisition
Manuscript Source	Unsolicited Manuscript
All Author List	Duanghathai Pasanta, Tipparat Kongseha and Suchart Kothan
Funding Agency and Grant Number	Funding Agency Grant Number Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Thailand
Corresponding Author	Suchart Kothan, PhD, Associate Professor, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroros Rd., Sripoom, Chiang Mai 50200, Thailand. suchart.kothan@cmu.ac.th
Key Words	Proton magnetic resonance spectroscopy; Metabolite; Muscle fiber orientation; Intramyocellular lipids; Extramyocellular lipids; Magnetic susceptibility
Core Tip	Proton magnetic resonance spectroscopy (1H MRS) is a technique that is widely used for intramyocellular lipids and extramyocellular lipids quantification in muscles, as evidenced in various studies. However, different muscle positions can potentially lead to inconsistency in metabolite quantification and can also impede interpretation of data, which can lead to misinformation. This study reveals that the muscle orientation at 0°, 30°, 60°, and 90° to the main magnetic field significantly affects the metabolite profile and quantification. The metabolite profile changes due to the muscle fiber orientation demonstrate that the positioning potentially causes inaccuracy in 1H-MRS spectrum analysis.
Citation	Pasanta D, Kongseha T, Kothan S. Effects of muscle fiber orientation to main magnetic field on muscle metabolite profiles for magnetic resonance spectroscopy acquisition. World J Radiol 2019; 11(1): 1-9

Received	2018-08-06 06:30
Peer-Review Started	2018-08-07 01:00
To Make the First Decision	2018-10-17 01:38
Return for Revision	2018-10-22 01:46
Revised	2018-11-14 16:22
Second Decision	2019-01-08 11:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-10 00:22
Articles in Press	2019-01-10 00:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-01-26 00:35

ISSN	1949-8470 (online)
Open Access
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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