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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 41442
Country of Manuscript Source Japan
Specialty Oncology
Manuscript Type Retrospective Study
Article Title Prognostic significance of perioperative tumor marker levels in stage II/III gastric cancer
Manuscript Source Invited Manuscript
All Author List Yasuhito Suenaga, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani and Yasuhiro Kodera
Funding Agency and Grant Number
Correspondence To Mitsuro Kanda, MD, PhD, Research Fellow, Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. m-kanda@med.nagoya-u.ac.jp
Keywords Gastric cancer; Carcinoembryonic antigen; Carbohydrate antigen 19-9; Perioperative levels; Prognosis
Core Tip Although the outcomes of patients with advanced gastric cancer have gradually improved with the development of adjuvant therapies, a large number of patients experience disease recurrence after curative gastrectomy. To optimize the management of each individual patient, accurate markers to predict prognosis are needed. In this multicenter dataset analysis, we found that evaluation of the serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels both before and after surgery provides more precise risk stratification of patients with stage II/III gastric cancer. Patients with high postoperative CEA and CA19-9 levels are at high risk of disease recurrence, and intensive postoperative management to detect hematogenous recurrences should be considered.
Citation Suenaga Y, Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, Asada T, Ishiyama A, Matsushita H, Tanaka C, Kobayashi D, Fujiwara M, Murotani K, Kodera Y. Prognostic significance of perioperative tumor marker levels in stage II/III gastric cancer. World J Gastrointest Oncol 2018; In press
Received
2018-08-16 02:31
Peer-Review Started
2018-08-17 09:23
To Make the First Decision
2018-10-08 07:30
Return for Revision
2018-10-10 00:59
Revised
2018-11-20 03:17
Second Decision
2018-11-30 08:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-05 18:53
Articles in Press
2018-12-05 18:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Fang-Fang Ji
Reviewer Code 03728442, and 03726737
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Revised Manuscript 41442-Review.doc
Peer-review Report 41442-Peer-review(s).pdf
Answering Reviewers 41442-Answering reviewers.pdf
Scientific Misconduct Check 41442-Scientific misconduct check.pdf
Scientific Editor Work List 41442-Scientific editor work list.pdf
Audio Core Tip 41442-Audio core tip.mp3
Biostatistics Review Certificate 41442-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 41442-Conflict-of-interest statement.pdf
Copyright License Agreement 41442-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 41442-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 41442-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 41442-Language certificate.pdf
Supplementary Material 41442-Supplementary material.docx