Publication Name	World Journal of Gastroenterology
Manuscript ID	41640
Country	Lebanon

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis
Manuscript Source	Unsolicited Manuscript
All Author List	Rim Serhal, Nagib Saliba, George Hilal, Mayssam Moussa, Ghada S Hassan, Oula El Atat and Nada Alaaeddine
Funding Agency and Grant Number
Corresponding Author	Nada Alaaeddine, PhD, Professor, Laboratoire d Immunologie Cellulaire, Moléculaire Centre Hospitalier, Université de Montréal, 900 rue saint dénis, Montreal 10482, Canada. naladdin@gu.edu.lb
Key Words	Hepatocellular carcinoma; Adipose-derived mesenchymal stem cells; Adipose-derived mesenchymal stem cell conditioned media; Proliferation; Apoptosis; Migration; Invasion
Core Tip	In this study, we report the in vitro effect of adipose derived mesenchymal stem cells (ADMSCs) on HepG2 and PLC-PRF-5 liver cell lines. It is the first study to demonstrate that ADMSCs and their respective conditioned media inhibited the expression of hepatocellular carcinoma markers alpha-fetoprotein and Des-gamma-carboxy-prothrombin and decreased cancer cell invasiveness by increasing the mRNA expression of tissue inhibitor metalloproteinases TIMP-1, TIMP-2 and TIMP-3. In addition, ADMSCs significantly reduced the proliferation rate, the invasiveness and the migration of the cancer cells while inducing their apoptosis.
Citation	Serhal R, Saliba N, Hilal G, Moussa M, Hassan G, El Atat O, Alaaeddine N. Effect of adipose derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis. World J Gastroenterol 2019; 25(5): 567-583

Received	2018-09-10 07:30
Peer-Review Started	2018-09-10 07:41
To Make the First Decision	2018-10-11 09:15
Return for Revision	2018-10-12 02:20
Revised	2018-12-02 15:04
Second Decision	2018-12-06 10:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-12-07 03:32
Articles in Press	2018-12-07 03:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-12-18 03:55
Typeset the Manuscript	2019-01-29 06:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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