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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 41708
Country of Manuscript Source United Kingdom
Specialty Oncology
Manuscript type Retrospective Study
Article Title Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice
Manuscript Source Invited Manuscript
All Author List Alexander JP Fulton, Angela Lamarca, Christina Nuttall, Lynne McCallum, Rille Pihlak, Derek O'Reilly, Fiona Lalloo, Mairéad G McNamara, Richard A Hubner, Tara Clancy and Juan W Valle
Funding Agency and Grant Number
Correspondence To Angela Lamarca, MD, MSc, PhD, Doctor, Senior Lecturer, Senior Researcher, Department of Medical Oncology, The Christie NHS Foundation Trust, Division of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M204BX, United Kingdom. angela.lamarca@christie.nhs.uk
Keywords Genetic counselling; Pancreatic adenocarcinoma; Genetic consultation; BRCA; Germline
Core Tip Electronic records of consecutive patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) were reviewed retrospectively. The European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria were employed to identify patients eligible for genetic consultation referral. Out of 400 eligible patients, 113 (28.3% of the whole population) met referral criteria, only 10 (8.8%) were referred for genetic opinion. There was a low referral rate even for patients fulfilling EUROPAC criteria and a significant number of patients did not attend the consultation due to deteriorating performance status. Earlier referral, and increased awareness may optimise genetic services referral for patients with PDAC.
Citation Fulton AJP, Lamarca A, Nuttall C, McCallum L, Pihlak R, O’Reilly D, Lalloo F, McNamara MG, Hubner RA, Clancy T, Valle JW. Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice. World J Gastrointest Oncol 2019; 11(2): 102-116
Received
2018-08-30 06:16
Peer-Review Started
2018-08-30 08:25
To Make the First Decision
2018-10-29 02:56
Return for Revision
2018-10-30 01:01
Revised
2018-12-24 09:33
Second Decision
2019-01-08 11:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-10 06:38
Articles in Press
2019-01-10 06:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-02-15 01:24
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma
Reviewer Code 00112071
Editorial Director Fang-Fang Ji (Quit in 2019)
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor Ying-Na Bian (Quit in 2019)
Responsible Electronic Editor Ying-Na Bian (Quit in 2019)
Responsible Science Editor Jin-Lei Wang
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJGO-11-102.pdf
Full Article (Word) WJGO-11-102.docx
Manuscript File 41708-Review.docx
Answering Reviewers 41708-Answering reviewers.pdf
Audio Core Tip 41708-Audio core tip.m4a
Biostatistics Review Certificate 41708-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 41708-Conflict-of-interest statement.pdf
Copyright License Agreement 41708-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 41708-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 41708-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 41708-Non-Native Speakers of English Editing Certificate.doc
Supplementary Material 41708-Supplementary-Material-revision.docx
Peer-review Report 41708-Peer-review(s).pdf
Scientific Misconduct Check 41708-Scientific misconduct check.pdf
Scientific Editor Work List 41708-Scientific editor work list.pdf