Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	41708
Country	United Kingdom

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice
Manuscript Source	Invited Manuscript
All Author List	Alexander JP Fulton, Angela Lamarca, Christina Nuttall, Lynne McCallum, Rille Pihlak, Derek O'Reilly, Fiona Lalloo, Mairéad G McNamara, Richard A Hubner, Tara Clancy and Juan W Valle
Funding Agency and Grant Number
Corresponding Author	Angela Lamarca, MD, MSc, PhD, Doctor, Senior Lecturer, Senior Researcher, Department of Medical Oncology, The Christie NHS Foundation Trust, Division of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M204BX, United Kingdom. angela.lamarca@christie.nhs.uk
Key Words	Genetic counselling; Pancreatic adenocarcinoma; Genetic consultation; BRCA; Germline
Core Tip	Electronic records of consecutive patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) were reviewed retrospectively. The European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria were employed to identify patients eligible for genetic consultation referral. Out of 400 eligible patients, 113 (28.3% of the whole population) met referral criteria, only 10 (8.8%) were referred for genetic opinion. There was a low referral rate even for patients fulfilling EUROPAC criteria and a significant number of patients did not attend the consultation due to deteriorating performance status. Earlier referral, and increased awareness may optimise genetic services referral for patients with PDAC.
Citation	Fulton AJP, Lamarca A, Nuttall C, McCallum L, Pihlak R, O’Reilly D, Lalloo F, McNamara MG, Hubner RA, Clancy T, Valle JW. Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice. World J Gastrointest Oncol 2019; 11(2): 102-116

Received	2018-08-30 06:16
Peer-Review Started	2018-08-30 08:25
To Make the First Decision	2018-10-29 02:56
Return for Revision	2018-10-30 01:01
Revised	2018-12-24 09:33
Second Decision	2019-01-08 11:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-10 06:38
Articles in Press	2019-01-10 06:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-02-15 01:24

ISSN	1948-5204 (online)
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