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Publication Name World Journal of Hepatology
Manuscript ID 41893
Country of Manuscript Source Brazil
Specialty Gastroenterology and Hepatology
Manuscript type Minireviews
Article Title Hepatic encephalopathy: Lessons from preclinical studies
Manuscript Source Invited Manuscript
All Author List Luiza Cioglia Dias Lima, Aline Silva Miranda, Rodrigo Novaes Ferreira, Milene Alvarenga Rachid and Ana Cristina Simoes e Silva
Funding Agency and Grant Number
Correspondence To Ana Cristina Simoes e Silva, MD, PhD, Full Professor, Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, UFMG, Avenida Alfredo Balena, 190, 2o andar, sala 281, Belo Horizonte 30130-100, Minas Geris, Brazil. acssilva@hotmail.com
Keywords Hepatic encephalopathy; Acute liver failure; Preclinical studies; Hepatic cirrhosis; Neuroinflammation; Hyperammonemia
Core Tip Hepatic encephalopathy (HE) is a major complication closely related to the progression of end-stage liver disease. It can be subdivided according to the type of hepatic injury: type A, which results from acute liver failure, type B, which is associated with a portosystemic shunting without intrinsic liver disease, and type C, which is due to chronic liver disease. In this article, we have described the use of preclinical models to investigate HE. We have briefly described the applicability and the characteristics of these experimental models. In conclusion, preclinical models have allowed the comprehension of the pathways related to HE.
Citation Lima LCD, Miranda AS, Ferreira RN, Rachid MA, Simões e Silva AC. Hepatic encephalopathy: Lessons from preclinical studies. World J Hepatol 2019; 11(2): 173-185
Received
2018-08-29 01:35
Peer-Review Started
2018-08-29 06:25
To Make the First Decision
2018-10-19 06:05
Return for Revision
2018-10-19 09:52
Revised
2018-11-19 18:34
Second Decision
2019-01-22 10:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-28 21:58
Articles in Press
2019-01-28 21:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-02-24 06:13
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Xue-Jiao Wang
Reviewer Code 03529813, 03350345, and 00030603
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor Yan-Liang Zhang
Responsible Electronic Editor Yan-Liang Zhang
Responsible Science Editor Ya-Juan Ma
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJH-11-173.pdf
Full Article (Word) WJH-11-173.docx
Manuscript File 41893-Review.docx
Answering Reviewers 41893-Answering reviewers.pdf
Audio Core Tip 41893-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 41893-Conflict-of-interest statement.pdf
Copyright License Agreement 41893-Copyright license agreement.PDF
Non-Native Speakers of English Editing Certificate 41893-Language certificate.pdf
Peer-review Report 41893-Peer-review(s).pdf
Scientific Misconduct Check 41893-Scientific misconduct check.pdf
Scientific Editor Work List 41893-Scientific editor work list.pdf