Publication Name	World Journal of Hepatology
Manuscript ID	41893
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Hepatic encephalopathy: Lessons from preclinical studies
Manuscript Source	Invited Manuscript
All Author List	Luiza Cioglia Dias Lima, Aline Silva Miranda, Rodrigo Novaes Ferreira, Milene Alvarenga Rachid and Ana Cristina Simoes e Silva
Funding Agency and Grant Number
Corresponding Author	Ana Cristina Simoes e Silva, MD, PhD, Full Professor, Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, UFMG, Avenida Alfredo Balena, 190, 2o andar, sala 281, Belo Horizonte 30130-100, Minas Geris, Brazil. acssilva@hotmail.com
Key Words	Hepatic encephalopathy; Acute liver failure; Preclinical studies; Hepatic cirrhosis; Neuroinflammation; Hyperammonemia
Core Tip	Hepatic encephalopathy (HE) is a major complication closely related to the progression of end-stage liver disease. It can be subdivided according to the type of hepatic injury: type A, which results from acute liver failure, type B, which is associated with a portosystemic shunting without intrinsic liver disease, and type C, which is due to chronic liver disease. In this article, we have described the use of preclinical models to investigate HE. We have briefly described the applicability and the characteristics of these experimental models. In conclusion, preclinical models have allowed the comprehension of the pathways related to HE.
Citation	Lima LCD, Miranda AS, Ferreira RN, Rachid MA, Simões e Silva AC. Hepatic encephalopathy: Lessons from preclinical studies. World J Hepatol 2019; 11(2): 173-185

Received	2018-08-29 01:35
Peer-Review Started	2018-08-29 06:25
To Make the First Decision	2018-10-19 06:05
Return for Revision	2018-10-19 09:52
Revised	2018-11-19 18:34
Second Decision	2019-01-22 10:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-28 21:58
Articles in Press	2019-01-28 21:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-02-24 06:13

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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