Publication Name	World Journal of Biological Chemistry
Manuscript ID	41963
Country	Russia

Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Last decade update for three-finger toxins: Newly emerging structures and biological activities
Manuscript Source	Invited Manuscript
All Author List	Yuri N Utkin
Funding Agency and Grant Number	Funding Agency Grant Number The Russian Foundation for Basic Research 18-04-01075 The Russian Foundation for Basic Research 18-54-00031
Corresponding Author	Yuri N Utkin, DSc, PhD, Professor, Laboratory of Molecular Toxinology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Makllaya 16/10, V-437, Moscow 117997, Russia. utkin@mx.ibch.ru
Key Words	Three-finger toxins; Snake; Venom; Structure; Biological activity
Core Tip	The three-finger toxins (TFTs) of snake venoms are principal to and the most toxic components of elapid venoms. Over 700 TFT amino acid sequences are listed in the UniProt Knowledgebase currently, with new members added constantly. The past decade has also seen multitudinous new discoveries, including structural variations in TFTs (i.e. disulfide-bound dimers), new types of biological activities for the well-known TFTs (e.g., α-bungarotoxin’s inhibition of ionotropic receptors of γ-aminobutyric acid), and other new, unexpected activities for the TFTs (i.e. interaction with interleukin or insulin receptors and activation of sperm motility). This minireview provides an up-to-date overview of these data.
Citation	Utkin YN. Last decade update for three-finger toxins: Newly emerging structures and biological activities. World J Biol Chem 2019; 10(1): 17-27

Received	2018-09-01 03:35
Peer-Review Started	2018-09-03 01:34
To Make the First Decision	2018-10-29 03:01
Return for Revision	2018-10-30 01:19
Revised	2018-11-20 19:25
Second Decision	2018-11-30 09:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-12-05 17:59
Articles in Press	2018-12-05 17:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-24 08:01

ISSN	1949-8454 (online)
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