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Publication Name World Journal of Biological Chemistry
Manuscript ID 41963
Country of Manuscript Source Russia
Specialty Biochemistry and Molecular Biology
Manuscript Type Minireviews
Article Title Last decade update for three-finger toxins: Newly emerging structures and biological activities
Manuscript Source Invited Manuscript
All Author List Yuri N Utkin
Funding Agency and Grant Number
Funding Agency Grant Number
The Russian Foundation for Basic Research 18-04-01075
The Russian Foundation for Basic Research 18-54-00031
Correspondence To Yuri N Utkin, DSc, PhD, Professor, Laboratory of Molecular Toxinology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Makllaya 16/10, V-437, Moscow 117997, Russia. utkin@mx.ibch.ru; yutkin@yandex.ru
Keywords Three-finger toxins; Snake; Venom; Structure; Biological activity
Core Tip The three-finger toxins (TFTs) of snake venoms are principal to and the most toxic components of elapid venoms. Over 700 TFT amino acid sequences are listed in the UniProt Knowledgebase currently, with new members added constantly. The past decade has also seen multitudinous new discoveries, including structural variations in TFTs (i.e. disulfide-bound dimers), new types of biological activities for the well-known TFTs (e.g., α-bungarotoxin’s inhibition of ionotropic receptors of γ-aminobutyric acid), and other new, unexpected activities for the TFTs (i.e. interaction with interleukin or insulin receptors and activation of sperm motility). This minireview provides an up-to-date overview of these data.
Citation Utkin YN. Last decade update for three-finger toxins: Newly emerging structures and biological activities. World J Biol Chem 2018; In press
Received
2018-09-01 03:35
Peer-Review Started
2018-09-03 01:34
To Make the First Decision
2018-10-29 03:01
Return for Revision
2018-10-30 01:19
Revised
2018-11-20 19:25
Second Decision
2018-11-30 09:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-05 17:59
Articles in Press
2018-12-05 17:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1949-8454 (online)
Open Access This article is an open-access article, which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma
Reviewer Code 00504466
Editorial Director Fang-Fang Ji
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Revised Manuscript 41963-Review.doc
Peer-review Report 41963-Peer-review(s).pdf
Answering Reviewers 41963-Answering reviewers.pdf
Scientific Misconduct Check 41963-Scientific misconduct check.pdf
Scientific Editor Work List 41963-Scientific editor work list.pdf
Audio Core Tip 41963-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 41963-Conflict-of-interest statement.pdf
Copyright License Agreement 41963-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41963-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 41963-Language certificate.pdf