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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 42249
Country of Manuscript Source Italy
Specialty Oncology
Manuscript Type Retrospective Study
Article Title Redox, immune and genetic biomarker’s system for personalized treatments in colorectal cancer
Manuscript Source Invited Manuscript
All Author List Anna Maria Berghella, Anna Aureli, Angelica Canossi, Tiziana Del Beato, Alessia Colanardi and Patrizia Pellegrini
Funding Agency and Grant Number
Correspondence To Anna Maria Berghella, PhD, Research Scientist, Consiglio Nazionale delle Ricerche (CNR), Istituto di Farmacologia Traslazionale (IFT), via G Carducci, 32, L'Aquila 67100, AQ, Italy. annamaria.berghella@cnr.it
Keywords Aging and cancer biomarker; Cancer personalized treatments; Oxidation and immune biomarkers; Trx1/CD30 target; KIRs and FcR polymorphisms; Th cytokines; Aging and disease; Cancer-related mechanisms
Core Tip Identifying biomarkers able of point out the risk of development of degenerative processes linked to aging and colorectal cancer (CRC) onset, could improve clinical strategies. The aim was to establish if Trx1 and CD30 as dual target, combined with cytokines and polymorphisms of KIRs, FcRIIa-131H/R and FcRIIIa-158V/F, was more effective. Serum measures of Trx1/CD30, RTrx1, multiple cytokine levels and polymorphisms of KIR and FcγRIIa were used to estimate the effect of disease, age and gender to describe the variants in the biology of the redox immune system. Through these procedures, the redox immune fingerprint of health, ageing and cancer states was determined.
Citation Berghella AM, Aureli A, Canossi A, Del Beato T, Colanardi A, Pellegrini P. Redox, immune and genetic biomarker’s system for personalized treatments in colorectal cancer. World J Gastrointest Oncol 2019; In press
Received
2018-09-19 05:50
Peer-Review Started
2018-09-19 08:11
To Make the First Decision
2018-10-17 01:44
Return for Revision
2018-10-18 00:37
Revised
2018-12-11 10:15
Second Decision
2019-01-08 11:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-10 19:04
Articles in Press
2019-01-10 19:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Fang-Fang Ji
Reviewer Code 03119183, 03270518, 00070280, and 00068388
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Revised Manuscript 42249-Review.docx
Peer-review Report 42249-Peer-review(s).pdf
Answering Reviewers 42249-Answering reviewers.pdf
Scientific Misconduct Check 42249-Scientific misconduct check.pdf
Scientific Editor Work List 42249-Scientific editor work list.pdf
Audio Core Tip 42249-Audio core tip.mp3
Biostatistics Review Certificate 42249-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42249-Conflict-of-interest statement.pdf
Copyright License Agreement 42249-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 42249-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 42249-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 42249-Language certificate.pdf
Supplementary Material 42249-Supplementary material.pdf