Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	42249
Country	Italy

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Redox, immune and genetic biomarker’s system for personalized treatments in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Anna Maria Berghella, Anna Aureli, Angelica Canossi, Tiziana Del Beato, Alessia Colanardi and Patrizia Pellegrini
Funding Agency and Grant Number
Corresponding Author	Anna Maria Berghella, PhD, Research Scientist, Consiglio Nazionale delle Ricerche (CNR), Istituto di Farmacologia Traslazionale (IFT), via G Carducci, 32, L'Aquila 67100, AQ, Italy. annamaria.berghella@cnr.it
Key Words	Aging and cancer biomarker; Cancer personalized treatments; Oxidation and immune biomarkers; Trx1/CD30 target; KIRs and FcR polymorphisms; Th cytokines; Aging and disease; Cancer-related mechanisms
Core Tip	Identifying biomarkers able of point out the risk of development of degenerative processes linked to aging and colorectal cancer (CRC) onset, could improve clinical strategies. The aim was to establish if Trx1 and CD30 as dual target, combined with cytokines and polymorphisms of KIRs, FcRIIa-131H/R and FcRIIIa-158V/F, was more effective. Serum measures of Trx1/CD30, RTrx1, multiple cytokine levels and polymorphisms of KIR and FcγRIIa were used to estimate the effect of disease, age and gender to describe the variants in the biology of the redox immune system. Through these procedures, the redox immune fingerprint of health, ageing and cancer states was determined.
Citation	Berghella AM, Aureli A, Canossi A, Del Beato T, Colanardi A, Pellegrini P. Redox, immune and genetic biomarker’s system for personalized treatments in colorectal cancer. World J Gastrointest Oncol 2019; 11(2): 117-138

Received	2018-09-19 05:50
Peer-Review Started	2018-09-19 08:11
To Make the First Decision	2018-10-17 01:44
Return for Revision	2018-10-18 00:37
Revised	2018-12-11 10:15
Second Decision	2019-01-08 11:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-10 19:04
Articles in Press	2019-01-10 19:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-01-29 02:22
Typeset the Manuscript	2019-02-15 01:24

ISSN	1948-5204 (online)
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