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12/7/2018 2:49:11 AM | Browse: 413 | Download: 535
Publication Name World Journal of Gastroenterology
Manuscript ID 42308
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Clinical Trials Study
Article Title Molecular detection of epithelial-mesenchymal transition markers in circulating tumor cells from pancreatic cancer patients: Potential role in clinical practice
Manuscript Source Unsolicited Manuscript
All Author List Xiao-Hui Zhao, Zai-Rui Wang, Chang-Long Chen, Ling Di, Zhuo-Fei Bi, Zhi-Hua Li and Yi-Min Liu
Funding Agency and Grant Number
Funding Agency Grant Number
Guangdong Natural Science Foundation 2016A030313312
Corresponding Author Yi-Min Liu, MA, Associate Specialist, Professor, Department of Radiotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yan-Jiang Xi Road, Guangzhou 510120, Guangdong Province, China. liuyimin1995@sina.com
Key Words Pancreatic ductal adenocarcinoma; Circulating tumor cells; Epithelial-mesenchymal transition; Metastasis; Neutrophil-to-lymphocyte ratio
Core Tip In the present study, circulating tumor cell (CTC) enumeration and classification in pancreatic ductal adenocarcinoma (PDAC) patients were examined using the CanPatrol system. We explored the relationship between CTC status and survival and prognosis in 107 PDAC patients in China. CTC status was correlated with lymph node metastasis, TNM stage, distant metastasis, blood lymphocyte counts, neutrophil-to-lymphocyte ratio, and patient prognosis. Our findings demonstrate that CTCs show promise as a prognostic biomarker and provide useful evidence for determining an appropriate clinical approach for pancreatic adenocarcinoma patients.
Citation Zhao XH, Wang ZR, Chen CL, Ding L, Bi ZF, Lin Q, Li ZH, Liu YM. Molecular detection of epithelial-mesenchymal transition markers in circulating tumor cells from pancreatic cancer patients: Potential role in clinical practice. World J Gastroenterol 2018; 25(1): 138-150
Received
2018-10-13 08:26
Peer-Review Started
2018-10-15 07:12
To Make the First Decision
2018-11-08 06:22
Return for Revision
2018-11-08 07:00
Revised
2018-12-05 14:10
Second Decision
2018-12-06 10:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-07 02:49
Articles in Press
2018-12-07 02:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-12-14 04:36
Typeset the Manuscript
2019-01-06 10:19
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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