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12/7/2018 2:49:11 AM | Browse: 183 | Download: 15
Publication Name World Journal of Gastroenterology
Manuscript ID 42308
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript Type Clinical Trials Study
Article Title Molecular detection of epithelial-mesenchymal transition markers in circulating tumor cells from pancreatic cancer patients: Potential role in clinical practice
Manuscript Source Unsolicited Manuscript
All Author List Xiao-Hui Zhao, Zai-Rui Wang, Chang-Long Chen, Ling Di, Zhuo-Fei Bi, Zhi-Hua Li and Yi-Min Liu
Funding Agency and Grant Number
Funding Agency Grant Number
Guangdong Natural Science Foundation 2016A030313312
Correspondence To Yi-Min Liu, MA, Associate Specialist, Professor, Pro., Department of Radiotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yan-Jiang Xi Road, Guangzhou 510120, Guangdong Province, China. liuyimin1995@sina.com
Keywords Pancreatic ductal adenocarcinoma; Circulating tumor cells; Epithelial-mesenchymal transition; Metastasis; Neutrophil-to-lymphocyte ratio
Core Tip In the present study, circulating tumor cell (CTC) enumeration and classification in pancreatic ductal adenocarcinoma (PDAC) patients were examined using the CanPatrol system. We explored the relationship between CTC status and survival and prognosis in 107 PDAC patients in China. CTC status was correlated with lymph node metastasis, TNM stage, distant metastasis, blood lymphocyte counts, neutrophil-to-lymphocyte ratio, and patient prognosis. Our findings demonstrate that CTCs show promise as a prognostic biomarker and provide useful evidence for determining an appropriate clinical approach for pancreatic adenocarcinoma patients.
Citation Zhao XH, Wang ZR, Chen CL, Ding L, Bi ZF, Lin Q, Li ZH, Liu YM. Molecular detection of epithelial-mesenchymal transition markers in circulating tumor cells from pancreatic cancer patients: Potential role in clinical practice. World J Gastroenterol 2018; In press
Received
2018-10-13 08:26
Peer-Review Started
2018-10-15 07:12
To Make the First Decision
2018-11-08 06:22
Return for Revision
2018-11-08 07:00
Revised
2018-12-05 14:10
Second Decision
2018-12-06 10:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-07 02:49
Articles in Press
2018-12-07 02:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-12-14 04:36
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma
Reviewer Code 00504383, 00505755, 02441100, and 00070509
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor TQ Wang
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Revised Manuscript 42308-Review.docx
Peer-review Report 42308-Peer-review(s).pdf
Answering Reviewers 42308-Answering reviewers.pdf
Scientific Misconduct Check 42308-Scientific misconduct check.pdf
Scientific Editor Work List 42308-Scientific editor work list.pdf
Audio Core Tip 42308-Audio core tip.mp3
Biostatistics Review Certificate 42308-Biostatistics statement.pdf
Clinical Trial Registration Statement 42308-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 42308-Conflict-of-interest statement.pdf
Copyright License Agreement 42308-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42308-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 42308-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 42308-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 42308-Language certificate.pdf
Supplementary Material 42308-Supplementary material.pdf