Publication Name	World Journal of Gastroenterology
Manuscript ID	42352
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Modulation of faecal metagenome in Crohn’s disease: Role of microRNAs as biomarkers
Manuscript Source	Invited Manuscript
All Author List	María Rojas-Feria, Teresa Romero-García, Jose Ángel Fernández Caballero-Rico, Helena Pastor-Ramírez, Marta Avilés-Recio, Manuel Castro-Fernández, Natalia Chueca-Porcuna, Manuel Romero-Gómez, Federico Garcia, Lourdes Grande and José A Del Campo
Funding Agency and Grant Number	Funding Agency Grant Number Instituto de Salud Carlos III PI14/01349
Corresponding Author	José A Del Campo, PhD, Senior Scientist, Department of Digestive Diseases, Valme University Hospital, UGC Digestive Disease and CIBERehd, Avda. Bellvista s/n, Sevilla E-41014, Spain. jantonio.delcampo@ciberehd.org
Key Words	Crohn’s disease; Dysbiosis; microRNAs; Firmicutes; Bacteroidetes
Core Tip	In this study, we have found a shift in microbial gut community composition that supports dysbiosis in Crohn’s disease (CD) patients. The greatest interest of our work is that we have only included new-onset adult CD patients. We found that active non-treated CD patients had a low Firmicutes/Bacteroidetes ratio, less biodiversity in the structure of microbial communities and a significantly different pattern on gut microbiota distri­bution. Three microRNAs (miRNAs) have been found induced in affected mucosa vs non-affected mucosa in CD, indicating that miRNA profile may serve as biomarker for active disease.
Citation	Rojas-Feria M, Romero-García T, Fernández Caballero-Rico JÁ, Pastor Ramírez H, Avilés-Recio M, Castro-Fernandez M, Chueca Porcuna N, Romero-Gόmez M, García F, Grande L, Del Campo JA. Modulation of faecal metagenome in Crohn’s disease: Role of microRNAs as biomarkers. World J Gastroenterol 2018; 24(46): 5223-5233

Received	2018-09-19 05:55
Peer-Review Started	2018-09-19 06:55
To Make the First Decision	2018-11-01 06:53
Return for Revision	2018-11-01 09:01
Revised	2018-11-13 09:49
Second Decision	2018-11-16 07:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-11-16 18:39
Articles in Press	2018-11-16 18:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-12 03:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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