Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Integrated metabolomic profiling for analysis of antilipidemic effects of Polygonatum kingianum extract on dyslipidemia in rats
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Xing-Xin Yang, Jia-Di Wei, Jian-Kang Mu, Xin Liu, Jin-Cai Dong, Lin-Xi Zeng, Wen Gu, Jing-Ping Li and Jie Yu |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81660596 and 81760733 |
Application and Basis Research Project of Yunnan China |
2016FD050 and 2017FF117-013 |
Young and Middle-aged Academic and Technological Leader of Yunnan |
2015HB053 |
|
Corresponding Author |
Jie Yu, PhD, Professor, College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine, 1076 Yuhua Road, Kunming 650500, Yunnan Province, China. cz.yujie@gmail.com |
Key Words |
Dyslipidemia; Lipid regulation; Metabolomics; Multivariate statistical analysis; Polygonatum kingianum; Ultra-high performance liquid chromatography/mass spectrometry |
Core Tip |
We investigated the effects and the underlying mechanism of action of Polygonatum kingianum (P. kingianum) on high-fat diet (HFD)-induced dyslipidemia in rats using an integrated untargeted metabolomic method. The results indicated that P. kingianum alleviated HFD-induced dyslipidemia by regulating a large number of endogenous metabolites in serum, urine and liver. This involved phenylalanine, tyrosine, tryptophan, valine, leucine and isoleucine biosynthesis, and tryptophan, tyrosine, phenylalanine, starch, sucrose, glycerophospholipid, arachidonic acid, linoleic acid, nicotinate, nicotinamide and sphingolipid metabolism. P. kingianum may be a promising lipid regulator to remedy dyslipidemia and further alleviate its related diseases. |
Citation |
Yang XX, Wei JD, Mu JK, Liu X, Dong JC, Zeng LX, Gu W, Li JP, Yu J. Integrated metabolomic profiling for analysis of antilipidemic effects of Polygonatum kingianum extract on dyslipidemia in rats. World J Gastroenterol 2018; 24(48): 5505-5524 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |