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Publication Name World Journal of Gastroenterology
Manuscript ID 42384
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Integrated metabolomic profiling for analysis of antilipidemic effects of Polygonatum kingianum extract on dyslipidemia in rats
Manuscript Source Unsolicited Manuscript
All Author List Xing-Xin Yang, Jia-Di Wei, Jian-Kang Mu, Xin Liu, Jin-Cai Dong, Lin-Xi Zeng, Wen Gu, Jing-Ping Li and Jie Yu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81660596 and 81760733
Application and Basis Research Project of Yunnan China 2016FD050 and 2017FF117-013
Young and Middle-aged Academic and Technological Leader of Yunnan 2015HB053
Corresponding Author Jie Yu, PhD, Professor, College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine, 1076 Yuhua Road, Kunming 650500, Yunnan Province, China. cz.yujie@gmail.com
Key Words Dyslipidemia; Lipid regulation; Metabolomics; Multivariate statistical analysis; Polygonatum kingianum; Ultra-high performance liquid chromatography/mass spectrometry
Core Tip We investigated the effects and the underlying mechanism of action of Polygonatum kingianum (P. kingianum) on high-fat diet (HFD)-induced dyslipidemia in rats using an integrated untargeted metabolomic method. The results indicated that P. kingianum alleviated HFD-induced dyslipidemia by regulating a large number of endogenous metabolites in serum, urine and liver. This involved phenylalanine, tyrosine, trypto­phan, valine, leucine and isoleucine biosynthesis, and tryptophan, tyrosine, phenylalanine, starch, sucrose, glycero­phos­pholipid, arachidonic acid, linoleic acid, nicotinate, nicotina­mide and sphingolipid metabolism. P. kingianum may be a promising lipid regulator to remedy dyslipidemia and further alleviate its related diseases.
Citation Yang XX, Wei JD, Mu JK, Liu X, Dong JC, Zeng LX, Gu W, Li JP, Yu J. Integrated metabolomic profiling for analysis of antilipidemic effects of Polygonatum kingianum extract on dyslipidemia in rats. World J Gastroenterol 2018; 24(48): 5505-5524
Received
2018-09-25 00:48
Peer-Review Started
2018-09-25 02:39
To Make the First Decision
2018-10-24 01:39
Return for Revision
2018-10-24 06:55
Revised
2018-10-31 04:47
Second Decision
2018-11-16 07:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-11-16 18:40
Articles in Press
2018-11-16 18:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-11-21 01:54
Typeset the Manuscript
2018-12-26 03:07
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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