Publication Name	World Journal of Gastroenterology
Manuscript ID	42542
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over
Manuscript Source	Unsolicited Manuscript
All Author List	Oscar Caso-Maestro, Carlos Jiménez-Romero, Iago Justo-Alonso, Jorge Calvo-Pulido, David Lora-Pablos, Alberto Marcacuzco-Quinto, Félix Cambra-Molero, Alvaro García-Sesma, Marina Pérez-Flecha, Carlos Muñoz-Arce, Carmelo Loinaz-Segurola and Alejandro Manrique-Municio
Funding Agency and Grant Number
Corresponding Author	Oscar Caso-Maestro, MD, PhD, Associate Professor, Staff Physician, Surgeon, Unit of HBP Surgery and Abdominal Organs Transplantation, Department of General Surgery, ‘12 de octubre’ University Hospital, Av. Córdoba s/n, Madrid 28041, Spain. oscarcasomaestro@hotmail.com
Key Words	Liver transplantation; Aged donors; Old donors; Marginal donors; Donor age
Core Tip	The use of aged grafts is one of the main strategies to increase the number of available grafts. After analyzing the results of liver transplantation performed with donors ≥ 70 years old, we identified as independent predictors of graft survival: donor age X model for end-stage liver disease (D-MELD), recipient age and hepatitis C virus (HCV) infection. After combining D-MELD and recipient age we obtained a new scoring system that we called DR-MELD (donor age X recipient age X MELD), which seems to be a good measure to predict graft survival when using grafts ≥ 70 years old, regardless of the HCV infection.
Citation	Caso-Maestro O, Jiménez-Romero C, Justo-Alonso I, Calvo-Pulido J, Lora-Pablos D, Marcacuzco-Quinto A, Cambra-Molero F, García-Sesma A, Pérez-Flecha M, Muñoz-Arce C, Loinaz-Segurola C, Manrique-Municio A. Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over. World J Gastroenterol 2018; 24(47): 5391-5402

Received	2018-10-05 02:45
Peer-Review Started	2018-10-05 10:45
To Make the First Decision	2018-11-08 06:21
Return for Revision	2018-11-08 06:50
Revised	2018-11-24 13:02
Second Decision	2018-11-30 09:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-12-01 03:58
Articles in Press	2018-12-01 03:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-20 08:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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