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Publication Name World Journal of Hepatology
Manuscript ID 42566
Country of Manuscript Source Spain
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation
Manuscript Source Invited Manuscript
All Author List Maria Jesus Citores, Jose Luis Lucena, Sara de la Fuente and Valentin Cuervas-Mons
Funding Agency and Grant Number
Correspondence To Maria Jesus Citores, BSc, PhD, Research Scientist, Laboratory of Internal Medicine, Hospital Universitario Puerta de Hierro Majadahonda, Joaquin Rodrigo 2, Majadahonda 28222, Madrid, Spain. mariajesus.citores@salud.madrid.org
Keywords Hepatocellular carcinoma; Liver transplantation; Recurrence; Selection criteria; Prognostic score; Biomarker; Alpha-fetoprotein; Systemic inflammatory marker
Core Tip The Milan criteria for liver transplantation have improved survival of patients with small hepatocellular carcinoma (HCC), but up to 20% of patients still experience HCC recurrence after transplantation. Microvascular invasion and tumors with poor histologic grade of differentiation are the most important risk factors for HCC recurrence, but they are evidenced after surgery on explant pathology examination. Several surrogate pretransplant biomarkers, directly related with tumor biology or systemic inflammation markers conditioning tumor progression, have been suggested to identify, alone or integrated in pretransplant prognostic scores, patients at high risk of HCC recurrence after liver transplantation.
Citation Citores MJ, Lucena JL, de la Fuente S, Cuervas-Mons V. Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation. World J Hepatol 2019; 11(1): 50-64
Received
2018-09-28 02:24
Peer-Review Started
2018-09-28 08:07
To Make the First Decision
2018-10-22 00:20
Return for Revision
2018-10-24 03:04
Revised
2018-11-13 16:19
Second Decision
2018-12-03 00:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-05 17:44
Articles in Press
2018-12-05 17:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-01-24 12:45
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jin-Lei Wang
Reviewer Code 02530754, and 00054465
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor Wen-Wen Tan (Quit in 2019)
Responsible Electronic Editor Wen-Wen Tan (Quit in 2019)
Responsible Science Editor Jin-Lei Wang
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJH-11-50.pdf
Full Article (Word) WJH-11-50.docx
Manuscript File 42566-Review.docx
Answering Reviewers 42566-Answering reviewers.pdf
Audio Core Tip 42566-Audio core tip.wav
Conflict-of-Interest Disclosure Form 42566-Conflict-of-interest statement.pdf
Copyright License Agreement 42566-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 42566-Language certificate.pdf
Peer-review Report 42566-Peer-review(s).pdf
Scientific Misconduct Check 42566-Scientific misconduct check.pdf
Scientific Editor Work List 42566-Scientific editor work list.pdf