Publication Name	World Journal of Gastroenterology
Manuscript ID	42583
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Relationship between KRAS mutation status, expression of RAS pathway signaling molecules, and the clinicopathological features and prognosis of patients with colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Xiang-Bin Wan, Ai-Qin Wang, Jian Cao, Zhi-Chuang Dong, Ning Li, Sen Yang, Miao-Miao Sun, Zhi Li and Su-Xia Luo
Funding Agency and Grant Number	Funding Agency Grant Number the Henan Department of Science and Technology, China 162102310317
Corresponding Author	Su-Xia Luo, MD, Professor, Department of Medical Oncology, the Affiliated Cancer Hospital of Zhengzhou University, No. 127 Dongming Road, Jinshui District, Zhengzhou 450008, Henan Province, China. luoxiasu@126.com
Key Words	Colorectal cancer; KRAS gene; KRAS protein; BRAF protein; MEK protein; ERK protein
Core Tip	The RAS signaling pathway plays a crucial role in the invasiveness and metastasis of tumor cells. In the study, we examined the relationship between the KRAS gene mutation status and the clinicopathological features and prognosis of colorectal cancer (CRC) patients and the expression of BRAF, MEK, and ERK proteins. We found that KRAS gene mutations does not affect downstream protein expression or the clinicopathological features of CRC. KRAS protein is associated with poor tumor differentiation, older age, and a risk of tumor recurrence. The results may contribute to our understanding the drug resistance in KRAS mutant CRC.
Citation	Wan XB, Wang AQ, Cao J, Dong ZC, Li N, Yang S, Sun MM, Li Z, Luo SX. Relationship between KRAS mutation status, expression of RAS pathway signaling molecules, and the clinicopathological features and prognosis of patients with colorectal cancer. World J Gastroenterol 2019; 25(7): 808-823

Received	2018-11-14 03:19
Peer-Review Started	2018-11-14 07:35
To Make the First Decision	2018-12-05 06:10
Return for Revision	2018-12-05 08:38
Revised	2019-01-17 03:22
Second Decision	2019-01-21 03:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-21 04:16
Articles in Press	2019-01-21 04:16
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-01-24 08:38
Typeset the Manuscript	2019-02-20 10:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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