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Publication Name World Journal of Hepatology
Manuscript ID 42636
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Colorectal liver metastases: An update on multidisciplinary approach
Manuscript Source Invited Manuscript
All Author List Felix Che-Lok Chow and Kenneth Siu-Ho Chok
Funding Agency and Grant Number
Corresponding Author Kenneth Siu-Ho Chok, FRCS (Ed), Associate Professor, Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong , China. chok6275@hku.hk
Key Words Colorectal cancer; Liver metastases; Hepatic resection; Neoadjuvant therapy; Adjuvant chemotherapy; Intra-arterial therapy; Precision medicine; Multidisciplinary approach
Core Tip Surgery offers the only hope of cure in colorectal liver metastasis. It can be performed if complete metastasectomy is attainable. There is no consensus on the ideal management strategy for synchronous disease. A subset of patients presenting with unresectable disease may become eligible for resection after liver remnant augmentation or conversion therapy (chemo-therapeutics +/- biological agents). Amid increasing application of loco-regional therapies to colorectal liver metastasis, their role in the treatment paradigm remains to be defined. Refined patient selection – with greater emphasis on tumour biology – is essential to improving treatment outcome. The multidisciplinary approach helps determine the optimal treatment strategy from an expanding armamentarium of therapeutic options for each patient.
Citation Chow FCL, Chok KSH. Colorectal liver metastases: An update on multidisciplinary approach. World J Hepatol 2019; 11(2): 150-172
Received
2018-10-05 02:39
Peer-Review Started
2018-10-06 00:14
To Make the First Decision
2018-11-16 01:43
Return for Revision
2018-11-21 03:07
Revised
2018-11-24 03:54
Second Decision
2018-12-03 00:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-12-05 05:56
Articles in Press
2018-12-05 05:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-02-24 06:13
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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