Publication Name	World Journal of Gastroenterology
Manuscript ID	42697
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer: An update
Manuscript Source	Invited Manuscript
All Author List	Rafael I Jaén, Patricia Prieto, Marta Casado, Paloma Martín-Sanz and Lisardo Boscá
Funding Agency and Grant Number	Funding Agency Grant Number Ministerio de Ciencia Innovación y Universidades SAF2017-82436R, SAF2016-75004R Comunidad de Madrid S2017/BMD-3686 Fundación Ramón Areces 2016/CIVP18A3864 ISCIII-FEDER CIBERcv
Corresponding Author	Lisardo Boscá, BM BCh, PhD, Doctor, Professor, Senior Research Fellow, Department of Metabolism and Physiopathology of Inflammatory Diseases, Instituto de Investigaciones Biomédicas Alberto Sols, Arturo Duperier 4, Madrid 28029, Spain. lbosca@iib.uam.es
Key Words	Prostaglandins; Prostaglandin-endoperoxide synthase 2; Post-translational modifications; Glycosylation; Colorectal cancer; Inflammation
Core Tip	The post-translational modifications of prosta­glandin-endoperoxide synthase 2 (PTGS2) appear to be specific signatures of this enzyme in human colorectal cancer (CRC). Glycosylations of PTGS2 that alter the electrophoretic mobility of the protein are mainly ob­served in the tumor samples but are absent in the non-tumor samples obtained from these patients. These modifications not only may play a pathophysiological role in the progression of CRC but also may provide new biomarkers to develop specific therapeutic interventions.
Citation	Jaén RI, Prieto P, Casado M, Martín-Sanz P, Boscá L. Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer: An update. World J Gastroenterol 2018; 24(48): 5454-5461

Received	2018-10-07 06:00
Peer-Review Started	2018-10-07 08:43
To Make the First Decision	2018-11-08 06:25
Return for Revision	2018-11-08 07:36
Revised	2018-11-13 11:22
Second Decision	2018-11-16 07:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-11-16 18:45
Articles in Press	2018-11-16 18:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-26 02:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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