Publication Name	World Journal of Stem Cells
Manuscript ID	42749
Country	China

Category	Cell Biology
Manuscript Type	Review
Article Title	Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders
Manuscript Source	Unsolicited Manuscript
All Author List	Qiang Liu, Mo-Xian Chen, Lin Sun, Chloe U Wallis, Jian-Song Zhou, Li-Juan Ao, Qi Li and Pak C Sham
Funding Agency and Grant Number	Funding Agency Grant Number National Nature Science Foundation of China 81660381
Corresponding Author	Qi Li, PhD, Postdoctoral Fellow, Department of Psychiatry, the University of Hong Kong, 21 Sasson Roads, Pokfulam, Hong Kong , China. liqihku@gmail.com
Key Words	Autism spectrum disorders; Mesenchymal stem cells; Major histocompatibility complex; Inflammation; Maternal immune activation; Cell therapy
Core Tip	Autism spectrum disorder (ASD) is a complex, behaviorally defined disorder characterised by severe impairments in social communication and repetitive behavior. Because of an incomplete understanding of the pathology of ASD, available options of treatments in ASD are only symptomatic. We discuss the role of immune dysfunction in the etiology of ASD and function of mesenchymal stem cells (MSCs). We summerize the pre-clinical and clinical evidence for MSC therapy in ASD and suggest that more basic experiments are needed to better understanding of the therapeutic mechanisms of MSCs in ASD.
Citation	Liu Q, Chen MX, Sun L, Wallis CU, Zhou JS, Ao LJ, Li Q, Sham PC. Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders. World J Stem Cells 2019; 11(2): 55-72

Received	2018-10-09 10:07
Peer-Review Started	2018-10-10 01:25
To Make the First Decision	2018-11-29 07:49
Return for Revision	2018-12-06 07:28
Revised	2018-12-30 08:57
Second Decision	2019-01-22 01:26
Accepted by Journal Editor-in-Chief	2019-01-22 01:28
Accepted by Company Editor-in-Chief	2019-01-23 16:00
Articles in Press	2019-01-23 16:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-02-02 21:47
Typeset the Manuscript	2019-02-25 10:20

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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