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Publication Name World Journal of Cardiology
Manuscript ID 42784
Country of Manuscript Source United States
Specialty Cardiac and Cardiovascular Systems
Manuscript Type Editorial
Article Title Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β arrestins in the heart
Manuscript Source Invited Manuscript
All Author List Anastasios Lymperopoulos, Shelby L Wertz, Celina M Pollard, Victoria L Desimine, Jennifer Maning and Katie A McCrink
Funding Agency and Grant Number
Funding Agency Grant Number
NSU’s President’s Faculty Research and Development Grant (PFRDG)
Correspondence To Anastasios Lymperopoulos, BPharm, FAHA, MSc, PhD, Associate Professor, Research Associate, Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), College of Pharmacy, Nova Southeastern University, 3200 S. University Dr., HPD (Terry) Bldg/Room 1338, Fort Lauderdale, FL33328, United States. al806@nova.edu
Keywords Adverse remodeling; β arrestin; Biased signaling; Cardiac myocyte; Cardiac fibroblast; contractility; Functional divergence; G protein-coupled receptor; Heart failure; Hormone; Myocardial infarction; Signal transducer
Core Tip Presumed functionally similar for a long time, we now know that the two β arrestins display significant functional diversity in several organs and tissues, including in the cardiovascular system. Their functional distinction also in the mammalian heart has been clearly documented over the past few years. β arrestin-1, which is far more abundant than β arrestin-2 in almost every tissue including the myocardium, opposes the cyclic adenosine monophosphate (cAMP)-dependent pro-contractile signaling of the β1 adrenergic receptor (β1AR), and promotes cardiac apoptosis, inflammation, and other adverse remodeling-associated processes post-myocardial infarction. Conversely, β arrestin-2 promotes catecholamine-dependent cardiac contractility directly, via SERCA2a potentiation, and indirectly, by leaving β1AR’s cAMP-dependent pro-contractile signaling unaffected.
Citation Lymperopoulos A, Wertz SL, Pollard CM, Desimine VL, Manning J, McCrink KA. Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β arrestins in the heart. World J Cardiol 2019; In press
Received
2018-10-16 05:26
Peer-Review Started
2018-10-16 10:09
To Make the First Decision
2018-11-16 02:22
Return for Revision
2018-11-28 01:19
Revised
2018-11-28 21:54
Second Decision
2019-01-08 12:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-10 17:49
Articles in Press
2019-01-10 17:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1949-8462 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jin-Lei Wang
Reviewer Code 02634794, 03905734, and 02446542
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Revised Manuscript 42784-Review.docx
Peer-review Report 42784-Peer-review(s).pdf
Answering Reviewers 42784-Answering reviewers.pdf
Scientific Editor Work List 42784-Scientific editor work list.pdf
Audio Core Tip 42784-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 42784-Conflict-of-interest statement.pdf
Copyright License Agreement 42784-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42784-Grant application form(s).pdf